Chondrosarcoma of bone: does the size of the tumor, the presence of a pathologic fracture, or prior intervention have an impact on local control and survival?

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dc.contributor.authorPuri, Ajayen_US
dc.contributor.authorShah, Mandipen_US
dc.contributor.authorAgarwal, Manish Gen_US
dc.contributor.authorJambhekar, Nirmala Aen_US
dc.contributor.authorBasappa, Prabhudeven_US
dc.date.accessioned2009-01-19en_US
dc.date.accessioned2009-06-01T16:26:40Z
dc.date.available2009-01-19en_US
dc.date.available2009-06-01T16:26:40Z
dc.date.issued2009-01-19en_US
dc.description.abstractAIMS AND OBJECTIVES: We studied 45 patients with chondrosarcoma, without metastasis at diagnosis, who were surgically treated between January 2000 and December 2004 to evaluate the risk factors associated with local recurrence and metastasis. MATERIALS AND METHODS: Fourteen (31%) patients had had some major prior intervention, either in the form of an open biopsy or a curettage / unplanned excision, before presenting to us. Eight patients had pathologic fractures at presentation. None of the patients received adjuvant chemotherapy or radiotherapy. The follow-up duration ranged from 8-75 months. All survivors had a minimum follow-up of 36 months (range 36-75 months). RESULTS: There were 11 grade 1 (24.5%), 23 grade 2 (51%), and 11 grade 3 (24.5%) chondrosarcomas. Thirty-two (71%) patients had tumors that were larger than 8 cm in the greatest dimension. Margins were adequate in 31 patients. Twenty-five patients had disease relapse; there were four local failures, nine distant failures, and 12 combined failures. At the time of the last review, 12 patients had died, 11 were alive with disease, and 22 were free of disease. The cumulative event-free survival was 44% and the overall survival was 73%. CONCLUSION: Grade of tumor, size of tumor, and adequacy of resection might be important predictors of outcome. Local recurrence is a prelude to distant metastasis and portends poor ultimate survival. The presence of a pathological fracture could indicate biologically aggressive disease, and limb salvage in these cases should be advised with caution. Even in cases where there has been a prior unplanned intervention, local control can be achieved by subsequent adequate resection.en_US
dc.description.affiliationDepartment of Orthopaedic Oncology, Tata Memorial Hospital, Room No: 26, E Borges Road, Parel, Mumbai - 400 071, India. docpuri@vsnl.comen_US
dc.identifier.citationPuri A, Shah M, Agarwal MG, Jambhekar NA, Basappa P. Chondrosarcoma of bone: does the size of the tumor, the presence of a pathologic fracture, or prior intervention have an impact on local control and survival? Journal of Cancer Research and Therapeutics. 2009 Jan-Mar; 5(1): 14-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111556
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBone Neoplasms --mortality
dc.subject.meshBone Neoplasms --pathology
dc.subject.meshBone Neoplasms --surgery
dc.subject.meshChondrosarcoma --mortality
dc.subject.meshChondrosarcoma --pathology
dc.subject.meshChondrosarcoma --surgery
dc.subject.meshDisease-Free Survival
dc.subject.meshFemale
dc.subject.meshFractures, Spontaneous
dc.subject.meshHumans
dc.subject.meshKaplan-Meier Estimate
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Recurrence, Local
dc.subject.meshRisk Factors
dc.titleChondrosarcoma of bone: does the size of the tumor, the presence of a pathologic fracture, or prior intervention have an impact on local control and survival?en_US
dc.typeJournal Articleen_US
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