Helicobacter pylori infection in India from a western perspective.

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dc.contributor.authorThirumurthi, Selvi
dc.contributor.authorGraham, David Y
dc.date.accessioned2013-01-29T06:15:39Z
dc.date.available2013-01-29T06:15:39Z
dc.date.issued2012-10
dc.description.abstractHelicobacter pylori is a common bacterial infectious disease whose manifestations predominately affect the gastrointestinal tract. India is the prototypical developing country as far as H. pylori infection is concerned and more than 20 million Indians are estimated to suffer from peptic ulcer disease. Considering the high level of medical research and of the pharmaceutical industry, one would expect that India would be the source of much needed information regarding new therapies and approaches that remain effective in the presence of antimicrobial resistance, new methods to reliably prevent reinfection, and the development of therapeutic and preventive vaccines. Here we discuss H. pylori as a problem in India with an emphasis on H. pylori infection as a serious transmissible infectious disease. We discuss the pros and cons of eradication of H. pylori from the entire population and come down on the side of eradication. The available data from India regarding antimicrobial use and resistance as well as the effectiveness of various treatments are discussed. Rigorous ongoing studies to provide current regional antibiotic resistance patterns coupled with data concerning the success rate with different treatment regimens are needed to guide therapy. A systematic approach to identify reliably effective (e.g., 90% or greater treatment success) cost-effective regimens is suggested as well as details of regimens likely to be effective in India. H. pylori is just one of the health care problems faced in India, but one where all the resources are on hand to understand and solve it.en_US
dc.identifier.citationThirumurthi Selvi, Graham David Y. Helicobacter pylori infection in India from a western perspective. Indian Journal of Medical Research. 2012 Oct; 136(4): 549-562.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144782
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516022/en_US
dc.subjectAntibiotic resistanceen_US
dc.subjectepidemiologyen_US
dc.subjecteradicationen_US
dc.subjectHelicobacter pylorien_US
dc.subjectIndiaen_US
dc.subjecttreatmenten_US
dc.subject.meshHelicobacter Infections --drug therapy
dc.subject.meshHelicobacter Infections --epidemiology
dc.subject.meshHelicobacter Infections --prevention & control
dc.subject.meshHelicobacter Infections --surgery
dc.subject.meshHelicobacter Infections --therapy
dc.subject.meshHelicobacter Infections --transmission
dc.subject.meshHelicobacter pylori
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshPeptic Ulcer --drug therapy
dc.subject.meshPeptic Ulcer --epidemiology
dc.subject.meshPeptic Ulcer --prevention & control
dc.subject.meshPeptic Ulcer --surgery
dc.subject.meshPeptic Ulcer --therapy
dc.titleHelicobacter pylori infection in India from a western perspective.en_US
dc.typeArticleen_US
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