Amniotic membrane transplantation for reconstruction of corneal epithelial surface in cases of partial limbal stem cell deficiency.

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dc.contributor.authorSangwan, Virender Sen_US
dc.contributor.authorMatalia, Himanshu Pen_US
dc.contributor.authorVemuganti, Geeta Ken_US
dc.contributor.authorRao, Gullapalli Nen_US
dc.date.accessioned2004-12-08en_US
dc.date.accessioned2009-05-29T07:41:04Z
dc.date.available2004-12-08en_US
dc.date.available2009-05-29T07:41:04Z
dc.date.issued2004-12-08en_US
dc.description.abstractPURPOSE: To assess the efficacy of amniotic membrane for treatment of partial limbal stem cell deficiency (LSCD). METHODS: Medical records of four patients with partial LSCD who underwent pannus resection and amniotic membrane transplantation (AMT) were reviewed for ocular surface stability and improvement in visual acuity. Clinico-histopathological correlation was done with the resected pannus tissue. RESULTS: All the eyes exhibited stable corneal epithelial surface by an average of 7 weeks postoperatively with improvement in subjective symptoms. Best corrected visual acuity improved from preoperative (range: 6/9p-6/120) to postoperative (range: 6/6p-6/15) by an average of 4.5 lines on Snellen visual acuity charts. Histopathological examination of excised tissue showed features of conjunctivalisation. CONCLUSION: Amniotic membrane transplantation appears to be an effective means of reconstructing the corneal epithelial surface and for visual rehabilitation of patients with partial limbal stem cell deficiency. It may be considered as an alternative primary procedure to limbal transplantation in these cases.en_US
dc.description.affiliationSudhakar & Sreekanth Ravi Stem Cell Biology Laboratory, L V Prasad Eye Institute, Hyderabad, India. vsangwan@lvpei.orgen_US
dc.identifier.citationSangwan VS, Matalia HP, Vemuganti GK, Rao GN. Amniotic membrane transplantation for reconstruction of corneal epithelial surface in cases of partial limbal stem cell deficiency. Indian Journal of Ophthalmology. 2004 Dec; 52(4): 281-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/69625
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAdulten_US
dc.subject.meshAmnion --transplantationen_US
dc.subject.meshBiological Dressingsen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCorneal Diseases --pathologyen_US
dc.subject.meshEpithelium, Corneal --transplantationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLimbus Corneae --cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshStem Cell Transplantationen_US
dc.subject.meshStem Cells --pathologyen_US
dc.subject.meshVisual Acuityen_US
dc.titleAmniotic membrane transplantation for reconstruction of corneal epithelial surface in cases of partial limbal stem cell deficiency.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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