Comparison of effects of mass annual and biannual single dose therapy with diethylcarbamazine for the control of Malayan filariasis.

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dc.contributor.authorPanicker, K Nen_US
dc.contributor.authorKrishnamoorthy, Ken_US
dc.contributor.authorSabesan, Sen_US
dc.contributor.authorPrathiba, Jen_US
dc.contributor.authorAbidha,en_US
dc.date.accessioned2009-05-27T16:08:31Z
dc.date.available2009-05-27T16:08:31Z
dc.date.issued1991-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractAnnual and biannual mass single dose diethylcarbamazine citrate (DEC) at 6 mg/kg body weight was administered to people in a Brugia malayi endemic area in Shertallai part of Kerala, India, in 1987 and 1988. The coverage of population ranged between 41.33% and 66.01% in different rounds. The highest percentage of treated population developing side reactions was 8.4%. Both annual and biannual regimens were effective in reducing the microfilaria prevalence significantly from 4.90% to 1.23% and from 6.27% to 0.62% respectively and the incidence of infection was minimal in the adult population and zero among children. There was significant reduction in mean microfilaria count in both annual (81.08%) and biannual (98.00%) areas. Marked reduction in the proportion of high density carriers and infectivity index of the population after DEC therapy was also observed. Beneficial effect of mass single dose DEC on clinical cases of filariasis was evident from the reduction in the prevalence of acute manifestations, recent edema cases and the proportion of chronic cases with acute episodes. Results obtained from mass treatment areas were compared with those of the control area.en_US
dc.description.affiliationVector Control Research Centre, Indian Council of Medical Research, Indira Nagar, Pondicherry.en_US
dc.identifier.citationPanicker KN, Krishnamoorthy K, Sabesan S, Prathiba J, Abidha . Comparison of effects of mass annual and biannual single dose therapy with diethylcarbamazine for the control of Malayan filariasis. The Southeast Asian Journal of Tropical Medicine and Public Health. 1991 Sep; 22(3): 402-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34513
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDiethylcarbamazine --administration & dosageen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFilariasis --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshMalaysia --epidemiologyen_US
dc.subject.meshMass Screeningen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.titleComparison of effects of mass annual and biannual single dose therapy with diethylcarbamazine for the control of Malayan filariasis.en_US
dc.typeJournal Articleen_US
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