Herpes simplex encephalitis: a diagnostic and therapeutic reapprisal.

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dc.contributor.authorSatishchandra, Pen_US
dc.contributor.authorNandini, Men_US
dc.contributor.authorShankar, S Ken_US
dc.contributor.authorVasudevarao, Ten_US
dc.contributor.authorRavi, Ven_US
dc.contributor.authorShenoy, P Ken_US
dc.contributor.authorChatterjee, Sen_US
dc.contributor.authorJain, Sen_US
dc.date.accessioned1993-05-01en_US
dc.date.accessioned2009-05-31T05:27:19Z
dc.date.available1993-05-01en_US
dc.date.available2009-05-31T05:27:19Z
dc.date.issued1993-05-01en_US
dc.description.abstractHerpes Simplex Encephalitis (HSE) appears to be underdiagnosed in India, though viral encephalitides constitutes an important entity with significant morbidity. With an upsurge in AIDS, HSE may perhaps emerge as an important opportunistic infection in future. We discuss the clinical features and laboratory evaluation of nine cases of HSE seen in the last 12 years at our center. Diagnosis was established by brain biopsy in one, virological studies in six and at autopsy in three. Immunocytochemically viral antigens could be localized in 4 biopsied/autopsied brain tissue and in CSF cells on a cytospin preparation in one. This has facilitated rapid diagnosis in our cases. Virus isolation was successful in two. Three subjects were treated with acyclovir and all survived with variable morbidity. Four patients expired and none of them had received any specific antiviral drugs. Rapid diagnosis and early treatment with acyclovir has been highlighted.en_US
dc.description.affiliationDepartment of Neurology, National Institute of Mental Health & Neuro Sciences (NIMHANS), Bangalore.en_US
dc.identifier.citationSatishchandra P, Nandini M, Shankar SK, Vasudevarao T, Ravi V, Shenoy PK, Chatterjee S, Jain S. Herpes simplex encephalitis: a diagnostic and therapeutic reapprisal. Journal of the Association of Physicians of India. 1993 May; 41(5): 277-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/95589
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAcyclovir --therapeutic useen_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsyen_US
dc.subject.meshBrain --microbiologyen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshEncephalitis --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpes Simplex --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleHerpes simplex encephalitis: a diagnostic and therapeutic reapprisal.en_US
dc.typeJournal Articleen_US
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