A comparative evaluation of pharmacokinetics of conventional and slow-release carbamazepine formulation in newly treated patients of epilepsy: a random evaluation.

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dc.contributor.authorNag, Den_US
dc.contributor.authorGarg, R Ken_US
dc.contributor.authorAgarwal, Aen_US
dc.date.accessioned1998-02-29en_US
dc.date.accessioned2009-05-31T01:10:35Z
dc.date.available1998-02-29en_US
dc.date.available2009-05-31T01:10:35Z
dc.date.issued1998-02-29en_US
dc.description.abstractStudy was conducted to compare the pharmacokinetic profile of conventional and slow-release carbamazepine formulations in Indian epileptic patients. Twenty consecutive untreated patients of partial seizures were randomly assigned to receive either conventional carbamazepine (200 mg thrice a day) or slow-release carbamazepine formulation (200 mg thrice a day), 10 patients in each group. The serum carbamazepine concentrations were measured on 10th day and 20th day of treatment. The blood samples were collected before the morning dose. In the conventional treatment group five patients experienced side effects as compared to two in the slow-release group. On 10th day mean serum carbamazepine levels were significantly higher in conventional group (8.27 +/- 1.39 micrograms/ml) in comparison to slow release group (4.28 +/- 3.89 micrograms/ml). The difference was statistically significant (p < 0.05). On 20th day carbamazepine levels fell significantly in conventional group only (8.27 +/- 1.39 micrograms/ml to 5.76 +/- 2.32 micrograms/ml, p < 0.05). At this stage the difference in mean carbamazepine levels of two groups became insignificant (p < 0.05). In conclusion, controlled release formulations provide more steady serum concentrations of carbamazepine along with better tolerability.en_US
dc.description.affiliationDepartment of Neurology, King George's Medical College, Lucknow.en_US
dc.identifier.citationNag D, Garg RK, Agarwal A. A comparative evaluation of pharmacokinetics of conventional and slow-release carbamazepine formulation in newly treated patients of epilepsy: a random evaluation. Journal of the Association of Physicians of India. 1998 Feb; 46(2): 185-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/91945
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshCarbamazepine --administration & dosageen_US
dc.subject.meshChemistry, Pharmaceuticalen_US
dc.subject.meshDelayed-Action Preparations --administration & dosageen_US
dc.subject.meshEpilepsy --diagnosisen_US
dc.subject.meshEvaluation Studies as Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProbabilityen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleA comparative evaluation of pharmacokinetics of conventional and slow-release carbamazepine formulation in newly treated patients of epilepsy: a random evaluation.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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