Effect of temperature and insecticide stresses on Aedes aegypti larvae and their influence on the susceptibility of mosquitoes to dengue-2 virus.

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dc.contributor.authorYadav, Pen_US
dc.contributor.authorBarde, P Ven_US
dc.contributor.authorGokhale, M Den_US
dc.contributor.authorVipat, Ven_US
dc.contributor.authorMishra, A Cen_US
dc.contributor.authorPal, J Ken_US
dc.contributor.authorMourya, D Ten_US
dc.date.accessioned2009-05-27T14:36:04Z
dc.date.available2009-05-27T14:36:04Z
dc.date.issued2005-09-28en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractTwo major factors, higher temperatures and the application of insecticides, can drastically alter the genetic structure of a vector mosquito population. Due to these two stresses, the majority of the population gets wiped out, but the ones that withstand the stress and survive are likely to pass on survivability, and have an altered physiology. Our study shows that exposures to higher temperatures and DDT during the larval stage affects their susceptibility as adult mosquitoes to the DEN-2 virus. The overall transcription and translation status of heat shock protein (Hsp70) in virus high- and low-susceptible was the same as that in other batches. In the case of a DDT-resistant (R-7) strain two bands were obtained during RT-PCRs after heat shock. These two alleles were obtained only with HY-1 in which R-7 males were used for the crosses, suggesting that the second allele is probably male sex linked. The higher expression of Hsp70 may provide DDT-resistant strains a better chance of survival high temperature environments, particularly in homozygotes and hybrids. It was also interesting to note that these strains have a significantly lower susceptibility to the virus. Wide-spread DDT-resistance and a rise in temperature above the average temperature during summer may result in a population with a low susceptibility to the virus. Several families of heat shock proteins are known to be expressed in mosquitoes, and may have a cumulative role in determining susceptibility to the virus, which itself is governed by several genes.en_US
dc.description.affiliationMicrobial Containment Complex, National Institute of Virology, Pashan, Pune, India.en_US
dc.identifier.citationYadav P, Barde PV, Gokhale MD, Vipat V, Mishra AC, Pal JK, Mourya DT. Effect of temperature and insecticide stresses on Aedes aegypti larvae and their influence on the susceptibility of mosquitoes to dengue-2 virus. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Sep; 36(5): 1139-44en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30569
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2005_36_5/11-3403.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCulicidae --geneticsen_US
dc.subject.meshDDTen_US
dc.subject.meshDengue Virus --geneticsen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshIndiaen_US
dc.subject.meshInsecticide Resistanceen_US
dc.subject.meshLarva --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMosquito Controlen_US
dc.subject.meshTemperatureen_US
dc.titleEffect of temperature and insecticide stresses on Aedes aegypti larvae and their influence on the susceptibility of mosquitoes to dengue-2 virus.en_US
dc.typeJournal Articleen_US
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