Preconditioning the human myocardium with intracoronary adenosine.

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dc.contributor.authorMehta, A Ben_US
dc.contributor.authorMardikar, H Men_US
dc.contributor.authorHiregouder, N Sen_US
dc.contributor.authorSethi, R Ben_US
dc.contributor.authorSolanki, D Ren_US
dc.date.accessioned1998-07-03en_US
dc.date.accessioned2009-05-27T04:27:18Z
dc.date.available1998-07-03en_US
dc.date.available2009-05-27T04:27:18Z
dc.date.issued1998-07-03en_US
dc.description.abstractThis study was designed to study the role of adenosine in ischaemic preconditioning. The clinical, electrocardiographic and metabolic parameters of ischaemia were compared before and after intracoronary adenosine during percutaneous transluminal coronary angioplasty in 15 patients with significant stenosis of the left anterior descending artery. Baseline ischaemia was demonstrated by inflating the balloon of appropriate size at its nominal pressure for 30 seconds. Intracoronary adenosine was then administered in dose of 1000 to 6000 mgm/ml. The balloon was repositioned and inflated at nominal pressure for 180 seconds. As compared to 1st balloon inflation, the 2nd balloon inflation produced less severe chest pain, less ST segment deviation on the intracoronary ECG (7.40 +/- 3.94 vs 4.30 +/- 2.15 mm; p < 0.05) and lower coronary sinus lactate levels as compared to the first (0.28 +/- 0.06 vs 0.22 +/- 0.04 mmol/lit; p < 0.05). In conclusion, this study proves that by injecting intracoronary adenosine it is possible to precondition the human myocardium.en_US
dc.description.affiliationDepartment of Cardiology, LTM Medical College and General Hospital, Mumbai.en_US
dc.identifier.citationMehta AB, Mardikar HM, Hiregouder NS, Sethi RB, Solanki DR. Preconditioning the human myocardium with intracoronary adenosine. Indian Heart Journal. 1998 Jul-Aug; 50(4): 397-401en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/5411
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdenosine --administration & dosageen_US
dc.subject.meshAdulten_US
dc.subject.meshAngioplasty, Transluminal, Percutaneous Coronaryen_US
dc.subject.meshCoronary Disease --pathologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intralesionalen_US
dc.subject.meshIschemic Preconditioning, Myocardial --methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVasodilator Agents --administration & dosageen_US
dc.titlePreconditioning the human myocardium with intracoronary adenosine.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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