Chronic granulomatous disease presenting with small bone osteomyelitis in a young child: A case report

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dc.contributor.authorChari, PSen_US
dc.contributor.authorChandra, Pen_US
dc.contributor.authorPrasad, Sen_US
dc.contributor.authorBhattad, Sen_US
dc.date.accessioned2020-04-10T01:49:30Z
dc.date.available2020-04-10T01:49:30Z
dc.date.issued2018-12
dc.description.abstractChronic granulomatous disease (CGD) is a life threatening inherited disorder with varied clinical presentations often characterized by recurrent bacterial and fungal infections along with widespread granulomatous tissue response. The disease results from phagocytic defects characterized by deficiencies in oxidative burst of neutrophils. Nitroblue tetrazolium reduction test (NBT) and Dihydrorhodamine (DHR) with PMA stimulation by flow cytometry are quick, simple, sensitive and specific laboratory tests that help establish early and reliable diagnosis of CGD with an overall improvement in survival and disease prognosis. We report a case of 2-year old child who presented with small bone osteomyelitis involving bilateral feet and was later diagnosed to have autosomal recessive CGD due to mutation in NCF1 gene.en_US
dc.identifier.affiliationsHematopathology and Immunohematology, Anand Diagnostic Laboratory, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Motherhood Hospital, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatric Immunology, Aster CMI Hospital, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationChari PS, Chandra P, Prasad S, Bhattad S. Chronic granulomatous disease presenting with small bone osteomyelitis in a young child: A case report. Indian Journal of Pathology and Microbiology. 2018 Dec; 61(4): 557-560en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196250
dc.languageenen_US
dc.publisherIndian Association of Pathologists and Microbiologistsen_US
dc.relation.issuenumber4en_US
dc.relation.volume61en_US
dc.source.urihttps://dx.doi.org/10.4103/IJPM.IJPM_458_17en_US
dc.subjectChronic granulomatous diseaseen_US
dc.subjectdihydrorhodamineen_US
dc.subjectnitroblue tetrazoliumen_US
dc.titleChronic granulomatous disease presenting with small bone osteomyelitis in a young child: A case reporten_US
dc.typeJournal Articleen_US
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