Screening of polymerization effect with Alginate-HPMC-Guar gum on Polymer-Based Interpenetrating Networks in Sodium Alginate Raft System for Sustained Drug Delivery

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dc.contributor.authorBarman, Shilaen_US
dc.contributor.authorSarkar, Arindamen_US
dc.contributor.authorMandal, Sanchitaen_US
dc.date.accessioned2025-06-19T05:53:18Z
dc.date.available2025-06-19T05:53:18Z
dc.date.issued2025-06
dc.description.abstractBackground: Various technologies have been developed recently, including creating controlled drug delivery systems to address several physiological challenges and gastric retention and emptying time. To combat this issue, new methods of medication delivery have been created. A recently developed technique called the raft-forming system can overcome several obstacles in the gastroretentive drug delivery system. Materials and Methods: This study was supervised to assess the effects of polymers like sodium alginate (SA), guar gum (GG), and hydroxypropyl methylcellulose (HPMC) and their grades in the formation of the raft. It showed the feasibility of prolonging the residence time in the stomach and the release rate of metronidazole, which was used here as a model drug. Four different HPMC grades were used (HPMC K100 M, HPMC K40 M, HPMC K15 M, and HPMC K4 M) with SA and calcium carbonate acting as divalent cation salt. The formed rafts were characterized by physical appearance, pH, in vitro gelling capacity, in vitro buoyancy study, shear stress by viscosity measurement, the density of raft, in vitro floating ability, raft volume, raft thickness, raft resilience, % swelling index, and Fourier transform infrared spectroscopy. Results: This formulation had no distinct difference in physical appearance, but HPMC 100 showed a deeper color than other formulations. pH ranged from 2 to 3, with HPMC 100 having the highest pH of 3. In situ, gelling capacity of HPMC 100 showed the lowest time of 5 s, and buoyancy capacity and resilience timing were the same for all more than 24 h and 4 h, respectively. Conclusion: The rest of the characterization of raft containing SA and HPMC 100 formulation takes the highest position. Based on the screening study, HPMC 100 demonstrated superior performance to other polymers and has been selected for further investigation.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationBarman Shila, Sarkar Arindam, Mandal Sanchita. Screening of polymerization effect with Alginate-HPMC-Guar gum on Polymer-Based Interpenetrating Networks in Sodium Alginate Raft System for Sustained Drug Delivery. International Journal of Pharmaceutical and Biological Archive. 2025 Jun; 16(2): 1-9en_US
dc.identifier.issn2582 – 6050
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249900
dc.languageenen_US
dc.publisherBRNSS PUBLICATION HUBen_US
dc.relation.issuenumber2en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22377/ijpba.v16i02.2181en_US
dc.subjectFloating lag timeen_US
dc.subjectguar gumen_US
dc.subjecthydroxypropyl methylcelluloseen_US
dc.subjectin situ gelen_US
dc.subjectraft volumeen_US
dc.subjectsodium alginateen_US
dc.titleScreening of polymerization effect with Alginate-HPMC-Guar gum on Polymer-Based Interpenetrating Networks in Sodium Alginate Raft System for Sustained Drug Deliveryen_US
dc.typeJournal Articleen_US
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