Clinical Profile of Scrub Typhus in Children and its Association with Hemophagocytic Lymphohistiocytosis.
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Date
2014-08
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Abstract
Objective: To study the clinical profile of children with scrub typhus and its association with
hemophagocytic lymphohistiocytosis. Methods: Children presenting with unexplained fever
and multi-systemic involvement between May to December 2011 were tested for scrub
typhus using IgM ELISA kits. Occurrence of Hemophagocytic lymphohistiocytosis in IgM
positive cases of scrub typhus was studied. Results: Of the 35 children with unexplained
fever and multi-systemic involvement, 15 children (9 boys) tested positive for scrub typhus.
Thrombocytopenia, hypoalbuminemia and raised hepatic transaminases were observed in
all children. Out of seven children evaluated for hemophagocytic lymphohistiocytosis. 3 met
the criteria for hemophagocytosis. Two children (one with hemophagocytic
lymphohistiocytosis) died. Conclusions: Scrub typhus is a common cause of unexplained
fever in children in northern India. Hemophagocytic lymphohistiocytosis can occasionally
complicate scrub typhus in children.
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Keywords
Infectious vasculitis, Rickettsial disease, Hemophagocytosis
Citation
Sankhyan Naveen, Saptharishi L G, Sasidaran Kandasamy, Kanga Anil, Singhi Sunit C. Clinical Profile of Scrub Typhus in Children and its Association with Hemophagocytic Lymphohistiocytosis. Indian Pediatrics. 2014 Aug; 51(8): 651-653.