Intramuscular Versus Oral Ondansetron for Management of Children with Acute Dehydrating Diarrhea and Vomiting: A Randomized Controlled Trial

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dc.contributor.authorSatyesh, Shubhamen_US
dc.contributor.authorMeena, Rajesh Kumaren_US
dc.contributor.authorShah, Dheerajen_US
dc.contributor.authorSaha, Rumpaen_US
dc.contributor.authorGupta, Piyushen_US
dc.date.accessioned2025-08-13T09:09:41Z
dc.date.available2025-08-13T09:09:41Z
dc.date.issued2025-06
dc.description.abstractOBJECTIVES To compare efficacy and safety of intramuscular (IM) ondansetron with oral ondansetron for improving u?liza?on of Oral Rehydra?on Therapy (ORT) by controlling vomi?ng in children with acute diarrhea and some dehydra?on. METHODS We enrolled children aged 3 months to 12 years presen?ng with acute diarrhea (dura?on < 14 days) with some dehydra?on, and at least two episodes of vomi?ng within last 6 h in an open-label randomized controlled trial. Par?cipants were randomized to receive single dose (0.2 mg/kg) of IM or oral ondansetron before star?ng ORT. Primary outcome was failure of ORT (persistence of some dehydra?on a?er 4 h of ORT or need for intravenous fluids). Secondary outcomes included need for unscheduled intravenous fluids, amount of Oral Rehydra?on Salt Solu?on (ORS) ingested a?er 4 h, frequency of vomi?ng episodes, adverse effects, and caregiver sa?sfac?on. RESULTS We randomized 60 children (31 IM, 29 oral); 58 (29 per group) were followed-up for all outcomes. There were no significant differences between IM and oral routes in terms of ORT failure (31% vs. 24.1%; RR (95% CI) 1.3 (0.5, 3.0), P = 0.557), need for IV fluids during ORT (24.1% vs. 20.7%; P = 0.753), mean (SD) ORS ingested (mL) in 4 h [616.2 (429.7) vs. 645.5 (403.5); P = 0.79], mean (SD) frequency of vomi?ng [1.4 (2.0) vs. 2.3 (2.4); P = 0.107] or caregiver sa?sfac?on. No adverse events a?ributable to the interven?on were observed. CONCLUSION Intramuscular ondansetron may not off er any advantage over oral use in management of children with acute diarrhea with vomi?ng and some dehydra?on.en_US
dc.identifier.affiliationsDepartment of Pediatrics, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi 110095, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi 110095, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi 110095, India; National Institute of Health and Family Welfare, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, New Delhi 110095, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi 110095, India.en_US
dc.identifier.citationSatyesh Shubham, Meena Rajesh Kumar, Shah Dheeraj, Saha Rumpa, Gupta Piyush . Intramuscular Versus Oral Ondansetron for Management of Children with Acute Dehydrating Diarrhea and Vomiting: A Randomized Controlled Trial. Indian Pediatrics. 2025 Jun; 62(6): 414-420en_US
dc.identifier.issn0019-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251346
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber6en_US
dc.relation.volume62en_US
dc.source.urihttps://indianpediatrics.net/june2025/414.pdfen_US
dc.subjectAcute gastroenteritisen_US
dc.subjectOral rehydration therapyen_US
dc.subjectSome dehydrationen_US
dc.subjectTreatment failureen_US
dc.titleIntramuscular Versus Oral Ondansetron for Management of Children with Acute Dehydrating Diarrhea and Vomiting: A Randomized Controlled Trialen_US
dc.typeJournal Articleen_US
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