Iterative ACORN as a high throughput tool in structural genomics.

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dc.contributor.authorSelvanayagam, Sen_US
dc.contributor.authorVelmurugan, Den_US
dc.contributor.authorYamane, Ten_US
dc.date.accessioned2006-08-01en_US
dc.date.accessioned2009-05-27T09:53:35Z
dc.date.available2006-08-01en_US
dc.date.available2009-05-27T09:53:35Z
dc.date.issued2006-08-01en_US
dc.description.abstractHigh throughput macromolecular structure determination is very essential in structural genomics as the available number of sequence information far exceeds the number of available 3D structures. ACORN, a freely available resource in the CCP4 suite of programs is a comprehensive and efficient program for phasing in the determination of protein structures, when atomic resolution data are available. ACORN with the automatic model-building program ARP/wARP and refinement program REFMAC is a suitable combination for the high throughput structural genomics. ACORN can also be run with secondary structural elements like helices and sheets as inputs with high resolution data. In situations, where ACORN phasing is not sufficient for building the protein model, the fragments (incomplete model/dummy atoms) can again be used as a starting input. Iterative ACORN is proved to work efficiently in the subsequent model building stages in congerin (PDB-ID: lis3) and catalase (PDB-ID: 1gwe) for which models are available.en_US
dc.description.affiliationDepartment of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India.en_US
dc.identifier.citationSelvanayagam S, Velmurugan D, Yamane T. Iterative ACORN as a high throughput tool in structural genomics. Indian Journal of Biochemistry & Biophysics. 2006 Aug; 43(4): 211-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28873
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAutomationen_US
dc.subject.meshCatalase --chemistryen_US
dc.subject.meshComputational Biology --instrumentationen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshEelsen_US
dc.subject.meshGalectins --chemistryen_US
dc.subject.meshGenomics --methodsen_US
dc.subject.meshMicrococcus luteus --metabolismen_US
dc.subject.meshModels, Chemicalen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshProtein Conformationen_US
dc.subject.meshProteins --chemistryen_US
dc.subject.meshProteomics --methodsen_US
dc.subject.meshSoftwareen_US
dc.titleIterative ACORN as a high throughput tool in structural genomics.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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