Role of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysis

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dc.contributor.authorVanaja, Maria Celestinaen_US
dc.contributor.authorJain, Jamal Mohammed Nurulen_US
dc.contributor.authorDalal, Ashwinen_US
dc.contributor.authorRanganath, Prajnyaen_US
dc.date.accessioned2023-08-19T04:51:52Z
dc.date.available2023-08-19T04:51:52Z
dc.date.issued2023-01
dc.description.abstractBackground & objectives: Calcium and vitamin D, separately or in combination are usually prescribed to prevent fragility fractures in elderly population. However, there are conflicting results regarding the ideal dosage and overall efficacy obtained from randomized controlled trials (RCTs) conducted in the past. The objective of this study was to assess the fracture risk with the administration of calcium or vitamin D alone or in combination in elderly population (>60 yr). Methods: PubMed, Cochrane and Embase databases were searched to identify the studies from inception to February 2021 with keywords, ‘vitamin D’, ‘calcium’ and ‘fracture’ to identify RCTs. The trials with comparing vitamin D, calcium or combination with either no medication or placebo were included for final analyses. The data were extracted and the study quality was assessed by two reviewers. The principal outcome measure was fractures around hip joint and secondary outcomes assessed were vertebral and any other fracture. Results: Eighteen RCTs were considered for the final analysis. Neither calcium nor vitamin D supplementation was associated with risk of fractures around hip joint [risk ratio (RR) 1.56; 95% confidence interval (CI), 0.91 to 2.69, I2=28%; P=0.11]. In addition, the combined administration of calcium and vitamin D was also not associated with fractures around the hip joint in comparison to either no treatment or placebo. The incidence of vertebral (RR 0.95; 95% CI, 0.82 to 1.10, I2=0%; P=0.49) or any other fracture (RR 0.83; 95% CI 0.65 to 1.06, I2=0%; P=0.14) was not significantly associated with the administration of calcium and vitamin D either individually or in combination. Further subgroup analysis of the results did not vary with the dosage of calcium or vitamin D, dietary calcium intake sex, or serum 25-hydroxyvitamin D levels. Interpretation & conclusions: The present meta-analysis of RCTs on calcium, vitamin D or a combination of the two in comparison to no treatment or placebo did not support the routine administration protocol of calcium and vitamin D either alone or in combination to lower the risk of fractures in elderly population.en_US
dc.identifier.affiliationsDepartments ofen_US
dc.identifier.affiliationsOrthopaedicsen_US
dc.identifier.affiliationsPathologyen_US
dc.identifier.affiliationsCommunity & Family Medicine, All India Institute of Medical Sciences, Bathindaen_US
dc.identifier.affiliationsDepartment of Nephrology, Dayanand Medical College & Hospital, Ludhianaen_US
dc.identifier.affiliationsDepartment of Community & Family Medicine, Guru Gobind Singh Medical College, Faridkot, Punjab, Indiaen_US
dc.identifier.citationKhatri Kavin, Kaur Manmeet, Dhir Tanish, Kankaria Ankita, Arora Hobinder. Role of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysis. Indian Journal of Medical Research. 2023 Jul; 158(1): 5-16en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223566
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume158en_US
dc.source.urihttps://doi.org/10.4103/ijmr.ijmr_1946_21en_US
dc.subject25-Hydroxyvitamin Den_US
dc.subjectcalciumen_US
dc.subjecthip fractureen_US
dc.subjectosteoporosisen_US
dc.subjectrisken_US
dc.subjectrandomized controlled trialsen_US
dc.subjectvitamin Den_US
dc.titleRole of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysisen_US
dc.typeJournal Articleen_US
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