The additional effect of 5% atorvastatin shampoo in the treatment of adult patients with mild to moderate seborrheic dermatitis of the scalp: A prospective, randomised, double-blind trial

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dc.contributor.authorMiri, Fen_US
dc.contributor.authorSadeghi, Men_US
dc.contributor.authorAbbaspour, Men_US
dc.contributor.authorSamadi, Sen_US
dc.contributor.authorYazdanpanah, MJ.en_US
dc.date.accessioned2025-06-18T11:42:22Z
dc.date.available2025-06-18T11:42:22Z
dc.date.issued2025-04
dc.description.abstractBackground: Seborrheic dermatitis (SD) is a long-lasting inflammatory skin condition that predominantly impacts regions abundant in sebaceous glands, including the scalp. Objectives: To assess the efficacy and anti-inflammatory effect of atorvastatin as an additive treatment among SD patients. Methods: In a prospective, randomised, double-blind trial, 46 patients over 18 years old with mild to moderate scalp SD were randomly assigned to receive either 2% ketoconazole shampoo or 2% ketoconazole shampoo plus 5% atorvastatin. The severity of dermatitis was assessed based on the symptom scale of seborrheic dermatitis (SSSD), and the variables of erythema, scaling, and itching, at baseline and 4 weeks after the intervention. Results: Based on our analyses, both treatment methods significantly reduced the SSSD scores. However, the average SSSD score in patients using ketoconazole shampoo plus atorvastatin decreased by an average of five points after 1 month. This reduction was comparable to the average decline of 3.5 points observed in the group using ketoconazole shampoo alone. Specifically, the severity of dermatitis, as assessed by the SSSD score, significantly decreased by 1.92 points more, in individuals using the atorvastatin-containing shampoo compared to the comparison group (P = 0.02). Limitation: This research was conducted at a single centre which limits the validity of the findings. Conclusion: The results of this study suggest that shampoo containing atorvastatin provides a statistically significant effect compared to ketoconazole shampoo alone, indicating its potential as an alternative treatment for SD. The treatment notably alleviates symptoms associated with scaling and itching which are the common manifestations of the condition.en_US
dc.identifier.affiliationsCutaneous Leishmaniasis Research Center, Mashhad, Iranen_US
dc.identifier.affiliationsDepartment of Epidemiology, School of Health, Mashhad, Iranen_US
dc.identifier.affiliationsTargeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad, Iranen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.identifier.affiliationsCutaneous Leishmaniasis Research Center, Mashhad, Iran.en_US
dc.identifier.citationMiri F, Sadeghi M, Abbaspour M, Samadi S, Yazdanpanah MJ.. The additional effect of 5% atorvastatin shampoo in the treatment of adult patients with mild to moderate seborrheic dermatitis of the scalp: A prospective, randomised, double-blind trial. Indian Journal of Dermatology, Venereology and Leprology. 2025 Apr; 91(2): 222-225en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249397
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber2en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_245_2024en_US
dc.subjectAnti-dandruff shampoosen_US
dc.subjectantifungalen_US
dc.subjectanti-inflammatoryen_US
dc.subjectatorvastatinen_US
dc.subjectseborrheic dermatitisen_US
dc.titleThe additional effect of 5% atorvastatin shampoo in the treatment of adult patients with mild to moderate seborrheic dermatitis of the scalp: A prospective, randomised, double-blind trialen_US
dc.typeJournal Articleen_US
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