Quantitative Analysis of specification of essential metals on wound healing
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Date
2007
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Publisher
University of Kelaniya: UK(ML).
Abstract
An assessment of essential metals in human wound fluid and wound tissue for concentrations and speciation with new, reliable, verified and validated technologies may be of value for the detection and remediation of essential metal based wound management. An attempt was taken here to gain the target. Samples were analyzed for essential metals using atomic absorption spectroscopy and well-established MINTEQA2 computer based chemical speciation program was used for speciation work. Zinc and copper seems to be progressively accumulated around the site of wound when the wound is healing whilst iron seems vise-versa. Calcium is stable with the healing of wound. Blood contains high levels of metals than acute and chronic wound tissues except for calcium. Iron levels of chronic tissues are higher than those in acute tissues whilst others vise-versa. Nutritional and non-nutritional factors are not much important to manipulate the metal ion concentration since neither any nutritional nor non-nutritional factor has a relationship with the variation of any analyzed metal ion concentration. The modeling studies indicate that distribution and bioavailability of zinc and manganese in the wound fluid depend upon the pH and healing of wound, whilst others not apparent. A successful study would aim ultimately to influence hospital expenditure by increasing the healing rate of wounds so that patients are discharged earlier and returned to the community with improved quality of life
Description
Dissertation: M.Phil., University of Kelaniya: UK(ML), 2007.
Keywords
Wound healing
Citation
RODRIGO, I, Quantitative Analysis of specification of essential metals on wound healing, University of Kelaniya UK(ML), 2007: xiv,122p.