Endoscopic, histologic and microbiologic evaluation of upper abdominal pain with special reference to Helicobacter pylori infection.

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dc.contributor.authorKumar, Men_US
dc.contributor.authorYachha, S Ken_US
dc.contributor.authorKhanduri, Aen_US
dc.contributor.authorPrasad, K Nen_US
dc.contributor.authorAyyagari, Aen_US
dc.contributor.authorPandey, Ren_US
dc.date.accessioned1996-11-01en_US
dc.date.accessioned2009-05-27T06:16:01Z
dc.date.available1996-11-01en_US
dc.date.available2009-05-27T06:16:01Z
dc.date.issued1996-11-01en_US
dc.description.abstractOBJECTIVE: To study children with significant upper abdominal pain of unidentifiable etiology and evaluate: (a) the relationship of pain to inflammatory esophago-gastro-duodenal lesions and Helicobacter pylori (HP) infection, and (b) the response to specific therapy. DESIGN: Prospective study. SETTING: Pediatric section of a tertiary referral gastroenterology center. SUBJECTS: Thirty three consecutive children with significant upper abdominal pain [mean age 9.9 +/- 2.7, range 4-15 years; 20 males] were subjected to upper gastrointestinal tract endoscopy and antral mucosal biopsies obtained for rapid urease test (RUT), Gram's staining of impression/crush smears and culture for HP and histologic examination. Patients with HP gastritis were treated with triple therapy, colloidal bismuth subcitrate, amoxycillin and metronidazole, for two weeks. At 8 weeks from the initiation of therapy, patients were re-evaluated for symptoms and HP eradication by repeat endoscopy and antral biopsies. Patients with esophagitis, gastritis and duodenitis without HP infection were treated with ranitidine for 6 weeks. All the patients were followed up for 6 months. RESULTS: Histology revealed antral gastritis in 28/33 (85%) patients. HP infection was present in 12/28 (43%) patients with antral gastritis. Symptomatic improvement with triple therapy was observed in 10/12 (83%) patients with HP gastritis and eradication of HP in 5/7. Improvement on ranitidine therapy was observed in 12/16 (75%) patients with HP negative gastritis. On follow-up, no patient with initial improvement with therapy had relapse of symptoms. CONCLUSION: Symptomatic children with HP related gastritis should be treated with triple therapy and HP negative gastritis with H2-receptor antagonist.en_US
dc.description.affiliationDepartment of Gastroenterology (Pediatric GE), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.en_US
dc.identifier.citationKumar M, Yachha SK, Khanduri A, Prasad KN, Ayyagari A, Pandey R. Endoscopic, histologic and microbiologic evaluation of upper abdominal pain with special reference to Helicobacter pylori infection. Indian Pediatrics. 1996 Nov; 33(11): 905-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/15804
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAbdominal Pain --microbiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDuodenitis --microbiologyen_US
dc.subject.meshEsophagitis --microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastritis --microbiologyen_US
dc.subject.meshHelicobacter Infections --complicationsen_US
dc.subject.meshHelicobacter pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.titleEndoscopic, histologic and microbiologic evaluation of upper abdominal pain with special reference to Helicobacter pylori infection.en_US
dc.typeJournal Articleen_US
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