Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts.
dc.contributor.author | Wanchu, A | en_US |
dc.contributor.author | Arora, S | en_US |
dc.contributor.author | Bhatnagar, A | en_US |
dc.contributor.author | Sud, A | en_US |
dc.contributor.author | Bambery, P | en_US |
dc.contributor.author | Singh, S | en_US |
dc.date.accessioned | 2004-04-22 | en_US |
dc.date.accessioned | 2009-05-29T13:15:26Z | |
dc.date.available | 2004-04-22 | en_US |
dc.date.available | 2009-05-29T13:15:26Z | |
dc.date.issued | 2004-04-22 | en_US |
dc.description.abstract | To determine if beta-2 microglobulin (beta2M) levels were elevated in our HIV infected patient population and if it could be used as a surrogate marker for disease progression. Thirty-eight HIV infected individuals and 26 age and sex-matched controls were studied. Measurement of CD4 cell count was carried out on a flowcytometer using anti-human CD4 monoclonal antibody and beta2M was measured by an enzyme immunoassay. Mean levels of HIV infected individuals were 1.29 +/- 0.52 mg/L and were significantly higher than 0.74 +/- 0.07 mg/L, the value of controls (p value <0.01). There was a negative correlation between CD4 counts and beta2M levels (r-value-0.79, p value <0.001). Beta2M levels in HIV infected individuals who have no opportunistic infection are elevated and these levels correlate with the CD4 counts. Beta2M can be used for the clinical follow-up of patients with HIV infection. | en_US |
dc.description.affiliation | Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. awanchu@yahoo.com | en_US |
dc.identifier.citation | Wanchu A, Arora S, Bhatnagar A, Sud A, Bambery P, Singh S. Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts. Indian Journal of Pathology & Microbiology. 2004 Apr; 47(2): 298-301 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/75458 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.ijpmonline.org | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Biological Markers --blood | en_US |
dc.subject.mesh | CD4 Lymphocyte Count | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | HIV Infections --blood | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | India | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | beta 2-Microglobulin --blood | en_US |
dc.title | Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts. | en_US |
dc.type | Journal Article | en_US |
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