Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts.

dc.contributor.authorWanchu, Aen_US
dc.contributor.authorArora, Sen_US
dc.contributor.authorBhatnagar, Aen_US
dc.contributor.authorSud, Aen_US
dc.contributor.authorBambery, Pen_US
dc.contributor.authorSingh, Sen_US
dc.date.accessioned2004-04-22en_US
dc.date.accessioned2009-05-29T13:15:26Z
dc.date.available2004-04-22en_US
dc.date.available2009-05-29T13:15:26Z
dc.date.issued2004-04-22en_US
dc.description.abstractTo determine if beta-2 microglobulin (beta2M) levels were elevated in our HIV infected patient population and if it could be used as a surrogate marker for disease progression. Thirty-eight HIV infected individuals and 26 age and sex-matched controls were studied. Measurement of CD4 cell count was carried out on a flowcytometer using anti-human CD4 monoclonal antibody and beta2M was measured by an enzyme immunoassay. Mean levels of HIV infected individuals were 1.29 +/- 0.52 mg/L and were significantly higher than 0.74 +/- 0.07 mg/L, the value of controls (p value <0.01). There was a negative correlation between CD4 counts and beta2M levels (r-value-0.79, p value <0.001). Beta2M levels in HIV infected individuals who have no opportunistic infection are elevated and these levels correlate with the CD4 counts. Beta2M can be used for the clinical follow-up of patients with HIV infection.en_US
dc.description.affiliationDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. awanchu@yahoo.comen_US
dc.identifier.citationWanchu A, Arora S, Bhatnagar A, Sud A, Bambery P, Singh S. Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts. Indian Journal of Pathology & Microbiology. 2004 Apr; 47(2): 298-301en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75458
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshCD4 Lymphocyte Counten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshbeta 2-Microglobulin --blooden_US
dc.titleBeta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts.en_US
dc.typeJournal Articleen_US
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