Comparative assessment of an Og4C3 ELISA and an ICT filariasis test: a study of Myanmar migrants in Thailand.

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dc.contributor.authorNuchprayoon, Surangen_US
dc.contributor.authorPorksakorn, Chantimaen_US
dc.contributor.authorJunpee, Alisaen_US
dc.contributor.authorSanprasert, Vivornpunen_US
dc.contributor.authorPoovorawan, Yongen_US
dc.date.accessioned2009-05-27T17:13:24Z
dc.date.available2009-05-27T17:13:24Z
dc.date.issued2003-12-17en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractDetection of circulating filarial antigen has now emerged as an alternative method for the diagnosis of bancroftian filariasis. We compared two antigen detection assays, an Og4C3 ELISA and an ICT (immunochromatography) Filariasis test, for the diagnosis of Wuchereria bancrofti infections in migrant Myanmar workers in Tak province, Western Thailand. A total of 337 Myanmars participated in this study. The microfilarial rate was 3.3%. The Og4C3 ELISA could detect 19.1% of bancroftian filariasis while the ICT test detected 12.7%. Both antigen assays could detect all microfilaremics. The Og4C3 ELISA detected 14.8% of amicrofilaremics while the ICT test identified 8.1%. Those who were positive for the ICT test were also positive by the Og4C3 ELISA. Those Og4C3 positive cases, that were ICT negative (ICT-ve/Og4C3+ve) had statistically significant (p < 0.05, unpaired t-test) lower Og4C3 antigen levels (409.5 units, range 117-2,389) than those that were ICT positive (ICT+ve/Og4C3+ve) (5,252.0 units, range 130-28,062). Our results emphasize the problem of bancroftian filariasis in Myanmar migrants working in Thailand. Close monitoring and control of this disease in Myanmar migrants are of public health importance. Antigen detection systems are promising tools for the surveillance of bancroftian filariasis.en_US
dc.description.affiliationDepartment of Parasitology, and Chula Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationNuchprayoon S, Porksakorn C, Junpee A, Sanprasert V, Poovorawan Y. Comparative assessment of an Og4C3 ELISA and an ICT filariasis test: a study of Myanmar migrants in Thailand. Asian Pacific Journal of Allergy and Immunology. 2003 Dec; 21(4): 253-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36720
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Helminth --analysisen_US
dc.subject.meshChilden_US
dc.subject.meshChromatographyen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFilariasis --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunologic Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyanmar --ethnologyen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshTransients and Migrantsen_US
dc.subject.meshWuchereria bancrofti --isolation & purificationen_US
dc.titleComparative assessment of an Og4C3 ELISA and an ICT filariasis test: a study of Myanmar migrants in Thailand.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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