Cytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases).

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dc.contributor.authorDubey, S
dc.contributor.authorChowdhury, M R
dc.contributor.authorPrahlad, B
dc.contributor.authorKumar, V
dc.contributor.authorMathur, R
dc.contributor.authorHamilton, S
dc.contributor.authorKabra, M
dc.contributor.authorMenon, P S N
dc.contributor.authorVerma, I C
dc.date.accessioned2012-11-26T09:57:05Z
dc.date.available2012-11-26T09:57:05Z
dc.date.issued2005-05
dc.description.abstractBACKGROUND: First trimester pregnancy loss is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important cause of recurrent pregnancy loss particularly in the first trimester. AIMS: In this study an evaluation of the contribution of chromosomal anomalies in causing repeated spontaneous abortions was made. METHODS AND MATERIALS: A review of the cytogenetic data in 742 couples (1484 individuals) with recurrent spontaneous abortions who were examined for chromosomal aberrations in the period 1990-2003 is presented. Women who had at least two abortions, or spontaneous abortions preceded or followed by fetal deaths or birth of a malformed child, and patients who had recurrent spontaneous abortions (> 3) with normal live issue/s were studied. RESULTS: Chromosomal rearrangements were found in 31 individuals (2%). These abnormalities included 22 (2.9%) structural aberrations, 9 (1.2%) numerical anomalies. In addition to these abnormalities, 21 (3.2%) chromosomal variants were also found. CONCLUSION: Chromosomal analysis is an important etiological investigation in couples with repeated spontaneous abortions as it helps in genetic counseling and deciding about further reproductive options.en_US
dc.identifier.citationDubey S, Chowdhury M R, Prahlad B, Kumar V, Mathur R, Hamilton S, Kabra M, Menon P S N, Verma I C. Cytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases). Indian Journal of Human Genetics. 2005 May; 11(2): 94-98.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/143337
dc.language.isoenen_US
dc.source.urihttps://www.ijhg.com/article.asp?issn=0971-6866;year=2005;volume=11;issue=2;spage=94;epage=98;aulast=Dubeyen_US
dc.subjectChromosomal abnormalitiesen_US
dc.subjectreciprocal translocationen_US
dc.subjectrecurrent spontaneous abortionen_US
dc.subjectRobertsonian translocationen_US
dc.titleCytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases).en_US
dc.typeArticleen_US
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