Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine.

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dc.contributor.authorVenkatraman, Nen_US
dc.contributor.authorO'Neil, Den_US
dc.contributor.authorHall, A Pen_US
dc.date.accessioned2008-10-28en_US
dc.date.accessioned2009-06-02T10:45:22Z
dc.date.available2008-10-28en_US
dc.date.available2009-06-02T10:45:22Z
dc.date.issued2008-10-28en_US
dc.description.abstractLamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.en_US
dc.description.affiliationAcute Care Common Stem, University Hospitals of Leicester NHS Trust, Intensive Care Unit, Leicester Royal Infirmary, Leicester, United Kingdom. navinda@doctors.org.uken_US
dc.identifier.citationVenkatraman N, O'Neil D, Hall AP. Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine. Journal of Postgraduate Medicine. 2008 Oct-Dec; 54(4): 316-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/115742
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshChlorpheniramine --administration & dosageen_US
dc.subject.meshCitalopram --administration & dosageen_US
dc.subject.meshElectrocardiography --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLong QT Syndrome --chemically induceden_US
dc.subject.meshOverdose --drug therapyen_US
dc.subject.meshPoisoning --drug therapyen_US
dc.subject.meshSodium Bicarbonate --therapeutic useen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshTriazines --administration & dosageen_US
dc.titleLife-threatening overdose with lamotrigine, citalopram, and chlorpheniramine.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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