Kasai Portoenterostomy at a Slightly Delayed Age and Native Liver Survival in Children With Biliary Atresia: Single Center Experience

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dc.contributor.authorRamakrishna, Somashekara Hosaagraharaen_US
dc.contributor.authorNayak, Samar Pratimen_US
dc.contributor.authorRao, Sanjayen_US
dc.contributor.authorDCruz, Ashley Lucien Josephen_US
dc.contributor.authorGarg, Mansien_US
dc.contributor.authorRamachandran, Kalyanien_US
dc.date.accessioned2023-08-25T06:40:00Z
dc.date.available2023-08-25T06:40:00Z
dc.date.issued2023-08
dc.description.abstractObjectives: We studied the modifiable prognostic factors that extend native liver survival at 2 years after Kasai portoenterostomy (KPE). Methods: We reviewed hospital records of patients with neonatal cholestasis, with focus on infants diagnosed with biliary atresia in a tertiary care hospital between January, 2014 and May, 2021. We determined the association of outcome with clinical and laboratory variables. Results: Infants who underwent KPE at a median (IQR) age of 76 (72-79) days had best outcomes, with minimal severe post-KPE complications and 2- year survival rate of 84.6%, compared to other infants (younger and older age at KPE). The median (IQR) weight at KPE in this group was 4.66 (4.2, 5.0) kg. Conclusions: In contrast to traditional recommendations, babies with median age at KPE of 76 days had superior native liver survival (84.6%) and reduced post-KPE complications, as compared to earlier KPE age. Nutritional status and weight of infant at KPE could be associated with this survival difference. This observation needs confirmation through multicentric prospective studies in different settings.en_US
dc.identifier.affiliationsDepartment of Pediatric Hepatology, Gleneagles Global Health City, Perumbakkam, Chennai, Tamil Naduen_US
dc.identifier.affiliationsDepartment of Pediatrics, Mazumdar Shaw Medical Centre, Narayana Health, Bangalore, Karnatakaen_US
dc.identifier.affiliationsDepartment ofPediatric Surgery and Division of Solid Organ Transplantation, Mazumdar Shaw Medical Centre, Narayana Health, Bangalore, Karnatakaen_US
dc.identifier.affiliationsIndependent Statistical Researcher, Bangalore, Karnatakaen_US
dc.identifier.affiliationsTejomir Diagnostics, Chennai, Tamil Nadu.en_US
dc.identifier.citationRamakrishna Somashekara Hosaagrahara, Nayak Samar Pratim, Rao Sanjay, DCruz Ashley Lucien Joseph, Garg Mansi, Ramachandran Kalyani. Kasai Portoenterostomy at a Slightly Delayed Age and Native Liver Survival in Children With Biliary Atresia: Single Center Experience. Indian Pediatrics. 2023 Aug; 60(8): 659-662en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225454
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber8en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/aug2023/659.pdfen_US
dc.subjectComplicationsen_US
dc.subjectLiver transplantationen_US
dc.subjectManagementen_US
dc.subjectOutcome.en_US
dc.titleKasai Portoenterostomy at a Slightly Delayed Age and Native Liver Survival in Children With Biliary Atresia: Single Center Experienceen_US
dc.typeJournal Articleen_US
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