Investigation of sex chromosome abnormalities in teratozoospermia of infertile men using fluorescence in situ hybridization.

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dc.contributor.authorAribarg, Aen_US
dc.contributor.authorNgeamvijawat, Jen_US
dc.contributor.authorChanprasit, Yen_US
dc.date.accessioned2009-05-27T18:11:56Z
dc.date.available2009-05-27T18:11:56Z
dc.date.issued2000-07-10en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractFluorescence in situ hybridization is a fast and efficient method of investigating chromosomal abnormalities in human spermatozoa. In this study, we have established the frequency of sex chromosome disomy (XX, XY and YY) in teratozoospermia (98-100% abnormal morphology) of infertile men compared with normospermic men using double-probe FISH procedures. A total of 40,000 sperms were scored in each group of semen for chromosome X and Y with overall hybridization efficiency of 97.00 per cent and 98.02 per cent in infertile men and normal men, respectively. It was found that the frequency of disomy XX, XY and YY was significantly higher in infertile men compared with normal men (P < 0.05). It is concluded that the infertile men showed increased frequencies of sex chromosomal abnormalities.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationAribarg A, Ngeamvijawat J, Chanprasit Y. Investigation of sex chromosome abnormalities in teratozoospermia of infertile men using fluorescence in situ hybridization. Journal of the Medical Association of Thailand. 2000 Jul; 83(7): 737-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38658
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshChromosome Aberrations --diagnosisen_US
dc.subject.meshChromosome Disordersen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfertility, Male --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOligospermia --diagnosisen_US
dc.subject.meshProbabilityen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSex Chromosomesen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.titleInvestigation of sex chromosome abnormalities in teratozoospermia of infertile men using fluorescence in situ hybridization.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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