Seroprevalence of Burkholderia pseudomallei in East Timorese refugees: implications for healthcare in East Timor.

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dc.contributor.authorArmstrong, P Ken_US
dc.contributor.authorAnstey, N Men_US
dc.contributor.authorKelly, P Men_US
dc.contributor.authorCurrie, B Jen_US
dc.contributor.authorMartins, Nen_US
dc.contributor.authorDasari, Pen_US
dc.contributor.authorKrause, Ven_US
dc.date.accessioned2009-05-27T15:40:59Z
dc.date.available2009-05-27T15:40:59Z
dc.date.issued2005-11-14en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractMelioidosis is a disease with protean clinical manifestations caused by the bacterium Burkholderia pseudomallei. It is endemic in countries surrounding the newly independent East Timor, but has yet to be isolated or demonstrated serologically in that country. One illness that can be clinically indistinguishable from melioidosis is pulmonary tuberculosis, a condition with a very high prevalence in East Timor. We used an indirect hemagglutination test (IHA) to measure antibodies to B. pseudomallei in 407 East Timorese evacuated to Darwin, Australia, in September 1999. Assuming a positive IHA titer as > or = 1:40, the overall seroprevalence rate was 17.0%, in keeping with other seroprevalence studies from the region. The IHA titres ranged up to 1:320. After adjusting for age, females were 2.5 times more likely to be seropositive than males (p = 0.0001). There was an inverse relationship between seropositivity and age. This study shows that exposure to B. pseudomallei occurs in East Timor melioidosis is also likely to occur. Due to the lack of laboratory facilities at present, it may be some time before a laboratory-confirmed case proves that melioidosis occurs. In the meantime, clinicians in East Timor should include melioidosis in the differential diagnosis of the many conditions that it may mimic.en_US
dc.description.affiliationCenter for Disease Control, Casuarina, Northern Territory, Australia. paarm@doh.health.nsw.gov.auen_US
dc.identifier.citationArmstrong PK, Anstey NM, Kelly PM, Currie BJ, Martins N, Dasari P, Krause V. Seroprevalence of Burkholderia pseudomallei in East Timorese refugees: implications for healthcare in East Timor. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Nov; 36(6): 1496-502en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33399
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2005_36_6/18-3610.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAntibodies, Bacterial --blooden_US
dc.subject.meshBurkholderia Infections --epidemiologyen_US
dc.subject.meshBurkholderia pseudomallei --immunologyen_US
dc.subject.meshDelivery of Health Careen_US
dc.subject.meshEast Timor --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemagglutination Testsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMelioidosis --epidemiologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRefugeesen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.titleSeroprevalence of Burkholderia pseudomallei in East Timorese refugees: implications for healthcare in East Timor.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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