Efficiency of Rabies Isolation by Using Mouse Neuroblastoma Cells
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Date
2011-02-02
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Bulletin of the Department of Medical Sciences - วารสารกรมวิทยาศาสตร์การแพทย์
Abstract
Rabies is an infectious agent in mammal which causes a fatal disease. In present severalcountries have an attempt to use cell culture for diagnosis and confirmation of rabies. In this study, we developedthe method for isolation of rabies virus in cell culture and evaluated its efficiency in comparison withmouse inoculation test (MIT). The result revealed that the cell isolation method has 100% sensitivity, specificityand efficiency, respectively when compared with mouse inoculation test method. From this study, the isolationand confirmation of rabies can be considered to substitute the cell culture method for the mouse inoculationtest method.Key word : Rabies, cell isolation, mouse inoculation, mouse neuroblastoma
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Bulletin of the Department of Medical Sciences - วารสารกรมวิทยาศาสตร์การแพทย์; Vol.50 No.1 January - March 2008; 35-43