The effect of H 1 and H 2 receptor antagonists on melanogenesis.

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dc.contributor.authorAnbar, Tag S
dc.contributor.authorWesterhof, Wiete
dc.contributor.authorBadawy, Nafisa A
dc.contributor.authorAbdel-Rahman, Amal T
dc.contributor.authorAbd El-Raheem, Talal A
dc.contributor.authorSayed, Saadea R
dc.contributor.authorAli, Azza H
dc.contributor.authorSalem, Hossam
dc.date.accessioned2012-09-04T07:14:20Z
dc.date.available2012-09-04T07:14:20Z
dc.date.issued2012-01
dc.description.abstractBackground: Histamine was found to stimulate melanogenesis in cultured human melanocytes specifically mediated by histamine H 2 receptors via protein kinase A activation. Based on this finding, the effect of topically applied H 2 antagonist on UVB-irradiated Guinea pigs' skin was examined and found to be suppressive on the post-irradiation melanogenesis. Aims: In this study, we tried to explore the role of topically applied H 1 and H 2 receptor antagonists, in inhibition of UVB-induced melanization. Methods: The effect of topically applied H 1 and H 2 receptor antagonists in inhibition of melanization was done clinically and histochemically using Fontana Masson and DOPA reactions compared with placebo. Results: The post-irradiation pigmentation was found to be brownish/black instead of the original light brown color. This color change occurred below the shaved orange-red fur suggesting a switch of melanogenesis from pheomelanin to eumelanin. The induced pigmentation was suppressed by topically applied H 2 antagonist while both H 1 antagonist and vehicle had no effect. The microscopic examination showed that the keratinocytes in the H 2 antagonist-treated areas contained few melanosomes while the nearby dendrites are full of them. Conclusion: H 2 antagonists' inhibition of UVB-induced pigmentation is not only due to suppression of melanization but also due to a specific action on melanosomes' transfer.en_US
dc.identifier.citationAnbar Tag S, Westerhof Wiete, Badawy Nafisa A, Abdel-Rahman Amal T, Abd El-Raheem Talal A, Sayed Saadea R, Ali Azza H, Salem Hossam. The effect of H 1 and H 2 receptor antagonists on melanogenesis. Indian Journal of Dermatology, Venereology and Leprology. 2012 Jan-Feb; 78(1): 64-67.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/140999
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=1;spage=64;epage=67;aulast=Anbaren_US
dc.subjectH 1 blockeren_US
dc.subjectH 2 blockeren_US
dc.subjecthistamineen_US
dc.subjectmelanocytesen_US
dc.subjectmelanosome transferen_US
dc.subjectmelanogenesisen_US
dc.titleThe effect of H 1 and H 2 receptor antagonists on melanogenesis.en_US
dc.typeArticleen_US
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