Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients.

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dc.contributor.authorThen, Sue-Mian
dc.contributor.authorRani, Zam Zureena Mohd
dc.contributor.authorRaymond, Azman Ali
dc.contributor.authorRatnaningrum, Safrina
dc.contributor.authorJamal, Rahman
dc.date.accessioned2012-01-12T07:25:59Z
dc.date.available2012-01-12T07:25:59Z
dc.date.issued2011-09
dc.description.abstractWe describe the association of the HLA-B*1502 allele in 27 epilepsy patients (19 Malays, 8 Chinese) treated with carbamazepine (CBZ) at the UKM Medical Center (UKMMC), 6 with CBZ-Steven Johnson Syndrome (CBZ-SJS), 11 with CBZ-induced rash, 2 with suspected phenytoin-induced rash and 8 negative controls. Our study showed that 10 (6 Malay, 4 Chinese) patients were positive for HLA-B*1502. Out of the 10 patients, six were confirmed to have CBZ-SJS (p =0.0006), while four patients developed a skin rash. However there were 6 Malay patients and 1 Chinese patient that developed a skin rash after CBZ administration who were not positive for the allele, indicating that there might be more that one allele associated with CBZ-induced hypersensitivity. Another 2 patients were suspected of having phenytoin-induced rash, instead of CBZ, and these patients did not have HLA-B*1502. In conclusion, this study confirmed the association of HLA-B*1502 with CBZ-SJS among Malaysian epilepsy patients, however there might be other genes that could be responsible for the CBZ-induced rash.en_US
dc.identifier.citationThen Sue-Mian, Rani Zam Zureena Mohd, Raymond Azman Ali, Ratnaningrum Safrina, Jamal Rahman. Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients. Asian Pacific Journal of Allergy and Immunology, 2011 Sept; 29(3): 290-293.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/136427
dc.language.isoenen_US
dc.source.urihttps://apjai.digitaljournals.org/index.php/apjai/article/viewFile/513/469en_US
dc.subjectHLA-B*1502 alleleen_US
dc.subjectcarbamazepineen_US
dc.subjectSteve-Johnson syndromeen_US
dc.subjectepilepsyen_US
dc.subjectdrug hypersensitivityen_US
dc.subjectpharmacogenomicsen_US
dc.titleFrequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients.en_US
dc.typeArticleen_US
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