Complications and residual pleural thickening after intrapleural instillation of streptokinase with pigtail catheter drainage of tuberculous pleural effusion

Simple item page
dc.contributor.authorH. S., Sandeepaen_US
dc.contributor.authorU., Narendraen_US
dc.contributor.authorGaude, Gajanan S.en_US
dc.contributor.authorSandeepa, Supriyaen_US
dc.date.accessioned2020-04-09T07:43:24Z
dc.date.available2020-04-09T07:43:24Z
dc.date.issued2020-01
dc.description.abstractBackground: Tuberculosis is the most common cause of exudative lymphocytic pleural effusion in India. Residual pleural thickening (RPT) is observed in about 50 percent of patients even after proper treatment with ATT. Pleural fluid drainage either with simple aspiration or with intercostal drainage and addition of corticosteroids along with antitubercular drugs have not shown to influence the incidence of RPT. The present study was undertaken to study the complications and residual effects of tubercular pleural effusion on the patients during the follow up period following intrapleural streptokinase instillation.Methods: Clinical profile, hospital course and outcome of tuberculous pleural effusion patients at the end of six months of anti-tubercular treatment of 50 patients from January 2009 to June 2010 were analyzed. These patients were randomly divided into two groups. One group (n=25) received intrapleural streptokinase via pigtail catheter and the other group (n=25) received intercostal drainage without intrapleural streptokinase instillation. All the patients received standard daily anti TB regimen of 2HERZ/4HR for a total duration of six months. All the patients were followed up for a total duration of 1 year for evidence of any residual pleural thickening.Results: Majority of the patients were above 40 years of age (60%). The male to female ratio was 2.3:1. The major symptoms of the patients were, fever in 44 patients (88%), cough in 42 patients (84%), breathlessness in 33 patients (66%), loss of appetite in 25 patients (50%) and chest pain in 25 patients (50%). Most of the patients had ADA levels between 40-70IU/L (48%) and only 6% had ADA levels below 40IU/L. The incidence of residual pleural thickening in the study group was less as compared to the control group (2.36�49mm vs 9.28�50mm) (p <0.0001).Conclusion: Intrapleural streptokinase instillation with pigtail catheter drainage less number of complications associated with study group and is successful with the decreased incidence of residual pleural thickening during the follow up period.en_US
dc.identifier.affiliationsDepartment of TB and Chest Disease, Akash Institute of Medical Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of TB and Chest Disease, Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of TB and Chest Disease, Jawaharlal Nehru Medical College, Belgaum, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Akash Institute of Medical Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationH. S. Sandeepa, U. Narendra, Gaude Gajanan S., Sandeepa Supriya. Complications and residual pleural thickening after intrapleural instillation of streptokinase with pigtail catheter drainage of tuberculous pleural effusion. International Journal of Advances in Medicine. 2020 Jan; 7(1): 1-5en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194533
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20195567en_US
dc.subjectPigtail catheteren_US
dc.subjectResidual pleural thickeningen_US
dc.subjectStreptokinaseen_US
dc.subjectTuberculosisen_US
dc.titleComplications and residual pleural thickening after intrapleural instillation of streptokinase with pigtail catheter drainage of tuberculous pleural effusionen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijam2020v7n1p1.pdf
Size:
122.15 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Advances in Medicine