Effect of centrally administered insulin on blood glucose levels in dogs.

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dc.contributor.authorAgarwala, G Cen_US
dc.contributor.authorMittal, R Ken_US
dc.contributor.authorBapat, S Ken_US
dc.contributor.authorBhardwaj, U Ren_US
dc.date.accessioned1977-01-01en_US
dc.date.accessioned2009-06-01T06:47:49Z
dc.date.available1977-01-01en_US
dc.date.available2009-06-01T06:47:49Z
dc.date.issued1977-01-01en_US
dc.description.abstractThe effects of minimal doses of insulin administered by intracerebroventricular (ICV) and intracisternal (IC) routes in mongrel dogs, on peripheral blood glucose level (BGL) have been studied. The dose of 0.1 U of insulin was found to be the minimal dose. This dose produced an immediate short lived hyperglycaemia followed by a marked and sustained hypoglycaemia. Both the effects were not observed in spinal cord transected-vagosympathectomised animals. The immediate hyperglycaemic effect was not observed in adrenalectomised animals whereas the subsequent hypoglycaemic effect did not appear only when the liver was removed. In an attempt to identify the precise site of action in the central nervous system (CNS), The cerebellomedullary angles were found to be the most sensitive sites for the action of locally applied insulin. It is suggested that insulin on central administration causes a rise in the BGL by an action on the adrenal glands and subsequently causes a marked fall in BGL by an action on the liver through some nerve fibers.en_US
dc.identifier.citationAgarwala GC, Mittal RK, Bapat SK, Bhardwaj UR. Effect of centrally administered insulin on blood glucose levels in dogs. Indian Journal of Physiology and Pharmacology. 1977 Jan-Mar; 21(1): 11-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107662
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdrenalectomyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshCisterna Magnaen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatectomyen_US
dc.subject.meshInjectionsen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshInsulin --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshPancreatectomyen_US
dc.subject.meshSpinal Cord --physiologyen_US
dc.subject.meshSympathectomyen_US
dc.subject.meshVagotomyen_US
dc.titleEffect of centrally administered insulin on blood glucose levels in dogs.en_US
dc.typeJournal Articleen_US
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