Primitive neuroectodermal tumors of kidney: Our experience in a tertiary care center.

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dc.contributor.authorSeth, A
dc.contributor.authorMahapatra, S K
dc.contributor.authorNayak, B
dc.contributor.authorSaini, A K
dc.contributor.authorBiswas, B
dc.date.accessioned2016-08-30T09:22:03Z
dc.date.available2016-08-30T09:22:03Z
dc.date.issued2016-01
dc.description.abstractOBJECTIVES: Primitive neuroectodermal tumors (PNET) are rare highly aggressive neoplasms. The diagnosis is made by histopathology with the support of immunohistochemistry (IHC) and cytogenetics. The aggressive multimodality treatment is recommended for the management of these tumors. The purpose of our study is to review our experiences in the diagnoses and treatment of PNET of the kidneys. MATERIALS AND METHODS: We retrospectively reviewed the data of all the patients, who were treated for the PNET of the kidneys at our institute between April and March 2011 and compared with the available literature. RESULTS: A total of eight patients were treated for PNET of the kidney. Out of the eight patients, four were males and four females. Nearly 50% of our patients had inferior vena caval thrombus at the time of presentation. The diagnosis was made on histopathology supported by IHC. Out of the eight patients, one patient had intraoperative death due to massive pulmonary thromboembolism and another died on the 7th post‑operative day due to disseminated intravascular coagulation and multiorgan failure. Rest six patients were treated with post‑operative chemotherapy or a combination of chemotherapy and radiotherapy. For these six patients, overall median survival was 45 months with a 3 year disease‑free survival of 66% and 5 year survival of 44%. CONCLUSIONS: PNET of the kidneys are rare peripheral neuroectodermal tumors with an aggressive clinical course. These tumors carry a very poor prognosis. An aggressive treatment approach using a combination of surgery, chemotherapy and radiotherapy is recommended for a reasonable survival in these tumors.en_US
dc.identifier.citationSeth A, Mahapatra S K, Nayak B, Saini A K, Biswas B. Primitive neuroectodermal tumors of kidney: Our experience in a tertiary care center. Indian Journal of Cancer. 2016 Jan-Mar; 53(1): 109-112.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176791
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2016;volume=53;issue=1;spage=109;epage=112;aulast=Sethen_US
dc.subjectChemotherapyen_US
dc.subjectprimitive neuroectodermal tumorsen_US
dc.subjectradiotherapyen_US
dc.subjectsurgeryen_US
dc.subjectvena caval thrombusen_US
dc.titlePrimitive neuroectodermal tumors of kidney: Our experience in a tertiary care center.en_US
dc.typeArticleen_US
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