Molecular mechanism of insulin resistance.

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dc.contributor.authorBhattacharya, Samiren_US
dc.contributor.authorDey, Debleenaen_US
dc.contributor.authorRoy, Sib Sankaren_US
dc.date.accessioned2007-03-17en_US
dc.date.accessioned2009-06-01T14:15:52Z
dc.date.available2007-03-17en_US
dc.date.available2009-06-01T14:15:52Z
dc.date.issued2007-03-17en_US
dc.description63 references.en_US
dc.description.abstractFree fatty acids are known to play a key role in promoting loss of insulin sensitivity,thereby causing insulin resistance and type 2 diabetes.However,the underlying mechanism involved is still unclear.In searching for the cause of the mechanism,it has been found that palmitate inhibits insulin receptor (IR)gene expression,leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKC(eta) causes this reduction in insulin receptor gene expression.One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies.We provide an overview of this important area,emphasizing the current status.en_US
dc.description.affiliationCellular and Molecular Endocrinology Laboratory, Department of Zoology, School of Life Science, Visva-Bharati (A Central University), Santiniketan 731 235, India. smrbhattacharya@yahoo.co.inen_US
dc.identifier.citationBhattacharya S, Dey D, Roy SS. Molecular mechanism of insulin resistance. Journal of Biosciences. 2007 Mar; 32(2): 405-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110705
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshFatty Acids, Nonesterified --metabolismen_US
dc.subject.meshGene Expression Regulation --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin --metabolismen_US
dc.subject.meshInsulin Resistance --physiologyen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshProtein Kinase C --metabolismen_US
dc.subject.meshReceptor, Insulin --metabolismen_US
dc.subject.meshSignal Transduction --physiologyen_US
dc.titleMolecular mechanism of insulin resistance.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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