Antimicrobial and Cytotoxic Activities of Endophytic Fungi Isolated from Artemisia annua L.

Simple item page
dc.contributor.authorAstuti, Puji
dc.contributor.authorWahyono
dc.contributor.authorNuryastuti, Titik
dc.contributor.authorPurwantini, Indah
dc.contributor.authorPurwanto
dc.date.accessioned2015-07-03T10:50:23Z
dc.date.available2015-07-03T10:50:23Z
dc.date.issued2014-10
dc.description.abstractThis study was aimed to investigate antimicrobial and cytotoxic effects of endophytic fungi isolated from A. annua L. The ethyl acetate extracts were obtained by liquid-liquid partition of fermentation broth of endophytes followed by evaporation. Antimicrobial assay was determined by disc diffusion method. Cytotoxicty assay was conducted against T47D, WiDr and Vero using MTT assay. Data generated were used to determine IC50. While DP2 extract did not show any inhibition against all tested bacteria, DP6 extract at 200 μg inhibited the growth of B. subtilis, P. aeruginosa and S. thypi with the highest inhibition against B. subtilis. Similarly, E2 extract inhibited the growth of B. subtilis, E. coli and S. thypi, with the highest inhibition against B. subtilis. The three extracts (DP2, DP6 and E2) were found to be cytotoxic against T47D and WiDr with E2 extract to be the most cytotoxic. These compounds were more selective against T47D cell line with IC50 of 91.7, 74.8 and 12.0 μg/mL, respectively. The IC50 against Vero cell line are 444.4, 140.3 and 87.7 μg/mL, respectively.en_US
dc.identifier.citationAstuti Puji, Wahyono, Nuryastuti Titik, Purwantini Indah, Purwanto. Antimicrobial and Cytotoxic Activities of Endophytic Fungi Isolated from Artemisia annua L. Journal of Applied Pharmaceutical Science. 2014 Oct; 4(10): 47-50.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158977
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1348en_US
dc.subjectantimicrobialen_US
dc.subjectcytotoxicen_US
dc.subjectfungal endophytesen_US
dc.subjectA. annua Len_US
dc.titleAntimicrobial and Cytotoxic Activities of Endophytic Fungi Isolated from Artemisia annua L.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
japs2014v4n10p47.pdf
Size:
165.81 KB
Format:
Adobe Portable Document Format
Description:
Research article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal of Applied Pharmaceutical Science (JAPS)