Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor.

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dc.contributor.authorManchana, Tarineeen_US
dc.contributor.authorSirisabya, Nakarinen_US
dc.contributor.authorLertkhachonsuk, Ruangsaken_US
dc.contributor.authorTresukosol, Damrongen_US
dc.date.accessioned2009-05-27T21:40:38Z
dc.date.available2009-05-27T21:40:38Z
dc.date.issued2006-08-20en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractA 17 year-old female with stage IIIc endodermal sinus tumor of the ovary developed transient cortical blindness and severe hypertension after 5 cycles of PVB regimen consisting of cisplatin, vinblastine and bleomycin. Clinical and radiological findings were compatible with Posterior LeukoEncephalopathy (PLE). Her visual acuity and blood pressure completely recovered within a few days after supportive treatment with antihypertensive drug. This condition is unpredictable but it can be reversible without long term sequelae. Most reports suggested that this rare toxicity was from cisplatin therapy. However, the exact pathophysiogenesis of this condition was not known precisely. Prompt reduction in blood pressure and withdrawal of immunosuppressive agents might lead to rapid reversal of this syndrome and prevent permanent brain damage.en_US
dc.description.affiliationGynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. T_manchana@hotmail.comen_US
dc.identifier.citationManchana T, Sirisabya N, Lertkhachonsuk R, Tresukosol D. Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. Journal of the Medical Association of Thailand. 2006 Aug; 89(8): 1265-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45208
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic useen_US
dc.subject.meshBleomycin --administration & dosageen_US
dc.subject.meshBlindness, Cortical --chemically induceden_US
dc.subject.meshBrain Diseases --chemically induceden_US
dc.subject.meshCisplatin --administration & dosageen_US
dc.subject.meshEndodermal Sinus Tumor --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshOvarian Neoplasms --drug therapyen_US
dc.subject.meshVinblastine --administration & dosageen_US
dc.titleTransient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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