Comparison of the effect of combinations of parentral artemisinin derivatives (I/M artemether, I/V artesunate) plus oral mefloquine with intravenous quinine plus oral tetracycline on patients with cerebral malaria: A multicentre trial (Preliminary Report)

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dc.contributor.authorTin Shween_US
dc.contributor.authorMyint Lwinen_US
dc.contributor.authorTan Myint Maungen_US
dc.contributor.authorKo Ko Hlaen_US
dc.contributor.authorHtin Aung Sawen_US
dc.contributor.authorSoe Aungen_US
dc.contributor.authorThan Htayen_US
dc.contributor.authorKyi Kyi Ngween_US
dc.contributor.authorKyin Htween_US
dc.contributor.authorHla Minen_US
dc.contributor.authorNilar Winen_US
dc.date.accessioned2009-06-30T09:02:50Z
dc.date.available2009-06-30T09:02:50Z
dc.date.created1996-04-01en_US
dc.date.issued1996-04-01en_US
dc.description.abstractIn order to find out the best drug combination for treatment of cerebral malaria at less equipped hospitals, 105 cases of cerebral malaria belonging to Mawlamyine, Pyin Oo Lwin and North Okkalapa hospitals were studied in a controlled trial of three regimens. (1) Intramuscular artemether total dose 480 mg plus mefloquine 750 mg in a single dose given through nasogastric tube at day 0. (2) Intravenous artesunate total dose 240 mg plus mefloquine 750 mg as in regimen 1. (3) Intravenous quinine dighdrochloride 600 mg in 180 ml infusion of dextrose saline given over 4 hours. The dose is repeated every 8 hours until the patient can swallow the tablets. Then oral quinine sulphate tablets were given 600 mg 8 hourly. Total period of quinine therapy is 7 days. Tetracycline 250 mg capsules were given 6 hourly for 7 days (started via nasogastric tube while the patient is unconscious). There was no significant difference in overall mortality rate, mean parasite clearance time, mean fever clearance time and mean time to regain consiousness between the three groups. Thus quinine-tetracycline (if necessary to supplement with artemether-mefloquine at 48 hours if the patient failed to respond to initial treatment) is suggested, as the drug of first choice for the management of cerebral malaria in Myanmar.en_US
dc.identifier.citationTin Shwe, Myint Lwin, Tan Myint Maung, Ko Ko Hla, Htin Aung Saw, Soe Aung, Than Htay, Kyi Kyi Ngwe, Kyin Htwe, Hla Min, Nilar Win. Comparison of the effect of combinations of parentral artemisinin derivatives (I/M artemether, I/V artesunate) plus oral mefloquine with intravenous quinine plus oral tetracycline on patients with cerebral malaria: A multicentre trial (Preliminary Report). Myanmar Health Sciences Research Journal. 1996; 8(1): 1-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/127088
dc.subject.meshMalaria, Cerebral-drug therapyen_US
dc.subject.meshQuinineen_US
dc.subject.meshMefloquineen_US
dc.subject.meshDrug Conbinationsen_US
dc.subject.meshMyanmaren_US
dc.titleComparison of the effect of combinations of parentral artemisinin derivatives (I/M artemether, I/V artesunate) plus oral mefloquine with intravenous quinine plus oral tetracycline on patients with cerebral malaria: A multicentre trial (Preliminary Report)en_US
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