Effect of administration of galactosamine hydrochloride on rat liver mitochondria.

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dc.contributor.authorPadma, Pen_US
dc.contributor.authorSetty, O Hen_US
dc.date.accessioned1997-06-01en_US
dc.date.accessioned2009-05-27T09:18:24Z
dc.date.available1997-06-01en_US
dc.date.available2009-05-27T09:18:24Z
dc.date.issued1997-06-01en_US
dc.description.abstractThe effect of galactosamine on liver mitochondrial functions was studied in vivo in rats at 12hr, 24hr and 36hr after the administration of the drug. State 3 respiration decreased significantly with both NAD+ linked and FAD linked substrates. Respiratory control ratio, an index of membrane integrity and P/O ratio which is a measure of phosphorylation efficiency decreased significantly. There was a significant decrease in the activities of NADH dehydrogenase, succinate dehydrogenase and cytochrome oxidase. A significant decrease was also seen on membrane potential, cytochrome aa3, cytochrome b, cytochrome c and on phospholipids of mitochondria. The observed mitochondrial dysfunctions were related to increased lipid peroxidation, which could cause loss of membrane integrity and a decreased rate of phosphorylation. It is proposed that increased lipid peroxidation was responsible for the inhibition on both oxidation and phosphorylation in mitochondria in galactosamine treated rats.en_US
dc.description.affiliationDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, India.en_US
dc.identifier.citationPadma P, Setty OH. Effect of administration of galactosamine hydrochloride on rat liver mitochondria. Indian Journal of Biochemistry & Biophysics. 1997 Jun; 34(3): 296-301en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27103
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Respiration --drug effectsen_US
dc.subject.meshCytochromes --analysisen_US
dc.subject.meshElectron Transport --drug effectsen_US
dc.subject.meshElectron Transport Complex IV --metabolismen_US
dc.subject.meshGalactosamine --pharmacologyen_US
dc.subject.meshLipid Peroxides --analysisen_US
dc.subject.meshLipids --analysisen_US
dc.subject.meshMitochondria, Liver --drug effectsen_US
dc.subject.meshNADH Dehydrogenase --metabolismen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshRatsen_US
dc.subject.meshSuccinate Dehydrogenase --metabolismen_US
dc.titleEffect of administration of galactosamine hydrochloride on rat liver mitochondria.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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