Prolonged intravascular hemolysisand vitamin B12 deficiencyafter parasiticclearance in a case of complicated falciparum malaria

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dc.contributor.authorChandra, SKen_US
dc.contributor.authorDastidar, AGen_US
dc.contributor.authorBandyopadhyay, Sen_US
dc.contributor.authorDutta, Aen_US
dc.contributor.authorSamanta, Ren_US
dc.contributor.authorGanguly, S.en_US
dc.date.accessioned2024-12-02T12:03:59Z
dc.date.available2024-12-02T12:03:59Z
dc.date.issued2024-07
dc.description.abstractBackground: Malaria is still a very threatening disease to tackle in India. The potential array of complications which can arise due to this infection is appreciably wide and many of these complications pose a significant life risk. Case report: Our patient, a 35-year-old gentleman presented with a complicated falciparum malaria infection. He developed an acute kidney insult, thrombocytopenia, septic shock, acidosis and anemia with a parasitemia of 3%. He was managed with artemisinin based therapy as per the latest guidelines and gradually his complications got tackled and he achieved parasitic clearance. But his anemia kept on worsening after fever resolution and parasitic clearence and he developed a picture of persistent intravascular hemolysis after recovery from the infection. Also, interestingly, his vitamin B12 level was significantly low despite being on a non-vegetarian diet and receiving oral B12 supplementation. Conclusion: This case highlights the importance of monitoring hemoglobin levels even after complete parasitic clearance as the intravascular hemolysis can also arise due to the usage of artemisinin based therapy, an entity called as post artemisinin delayed hemolysis. Also, this case showed the coexistence of low B12 state and poor B12 absorption in a young gentleman who had previously normal B12 levels. The association between malaria and poor B12 absorption needs to be explored further by more studies. Any association found can help in recommendations of B12 supplementation in malaria cases.en_US
dc.identifier.affiliationsDept. of General Medicine, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDept. of General Medicine, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDept. of General Medicine, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDept. of General Medicine, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDept. of General Medicine, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDept. of General Medicine, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationChandra SK, Dastidar AG, Bandyopadhyay S, Dutta A, Samanta R, Ganguly S. . Prolonged intravascular hemolysisand vitamin B12 deficiencyafter parasiticclearance in a case of complicated falciparum malaria. Journal of Applied Biology & Biotechnology. 2024 Jul; 11(3): 77-79en_US
dc.identifier.issn2319-1090
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/240872
dc.languageenen_US
dc.publisherIP Innovative Publication Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18231/j.sajcrr.2024.018en_US
dc.subjectFalciparumen_US
dc.subjectMalariaen_US
dc.subjectIntravascular hemolysisen_US
dc.subjectVitamin B12en_US
dc.titleProlonged intravascular hemolysisand vitamin B12 deficiencyafter parasiticclearance in a case of complicated falciparum malariaen_US
dc.typeJournal Articleen_US
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