Immunohistochemical expression of human epididymis 4 in ovarian malignancy

Simple item page
dc.contributor.authorNahar, Begum Afrinen_US
dc.contributor.authorSaha, Ramaen_US
dc.contributor.authorDas, Chhandaen_US
dc.contributor.authorKamilya, Gourishankaren_US
dc.date.accessioned2020-11-18T10:00:14Z
dc.date.available2020-11-18T10:00:14Z
dc.date.issued2019-12
dc.description.abstractBackground: Ovarian malignancies has the highest mortality rate among all gynaecological malignancies. Surface epithelial tumors form two thirds of all ovarian neoplasm and 90% of all ovarian cancers are surface epithelial carcinomas. Mortality in case of ovarian malignancy is high due to late diagnosis. Early and accurate diagnosis can improve the case specific management. HE4 (Human Epididymis Protein 4) which is proved to be overexpressed in the ovarian cancer cells, is considered a new biomarker for ovarian cancer diagnosis which helps in early diagnosis and patient management. Aims and objectives of the study was to evaluate the immunohistochemical expression of HE4 in various ovarian malignancies.Methods: It was a cross sectional, prospective, single institution-based study, conducted in the department of Pathology in collaboration with the Department of Gynaecology and Obstetrics, from December 2016 to January 2019 in institution. A total 74 ovarian malignancies were selected for this study.Results: Serous carcinoma was the most common ovarian malignancy followed by endometrioid carcinoma. Highest percentage of expression of HE4 was seen in high grade serous cancer and malignant endometrioid tumor.Conclusions: HE4 was highly expressed in malignant ovarian tumour especially serous and endometrioid carcinoma and can be used as an important biomarker for malignant ovarian neoplasm. Expression in high grade ovarian serous cancer support its prognostic value also.en_US
dc.identifier.affiliationsDepartment of Pathology, IPGME and R, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Gynaecology and Obstetrics, IPGME and R, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationNahar Begum Afrin, Saha Rama, Das Chhanda, Kamilya Gourishankar. Immunohistochemical expression of human epididymis 4 in ovarian malignancy. International Journal of Research in Medical Sciences. 2019 Dec; 7(12): 4696-4702en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211944
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20195506en_US
dc.subjectBiomarker, Immunohistochemical, Human epididymis protein 4, Ovarian malignancyen_US
dc.titleImmunohistochemical expression of human epididymis 4 in ovarian malignancyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijrms2019v7n12p4493.pdf
Size:
175.84 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Research in Medical Sciences