Anti-psoriatic evaluation of aloe emodin-loaded topical hydrogel in an imiquimod-induced human plaque-type psoriasis in BALB/c mice

Simple item page
dc.contributor.authorPandey, Aen_US
dc.contributor.authorSrivastava, Nen_US
dc.contributor.authorDubey, RCen_US
dc.contributor.authorDhaneshwar, Sen_US
dc.contributor.authorShukla, AKen_US
dc.date.accessioned2024-11-30T11:21:20Z
dc.date.available2024-11-30T11:21:20Z
dc.date.issued2024-09
dc.description.abstractAloe emodin, an anthraquinone derivative, mainly obtained from Aloe vera, possesses an extensive spectrum of pharmacological properties, including anti-proliferative, anticancer, wound healing, analgesic, anti-inflammatory, antibacterial, and antiviral properties. The objective of the present study was to prepare aloe emodin-loaded topical hydrogel formulations for managing plaque-type psoriasis. Different proportions of carbopol 940, chitosan, and hydroxyl propyl methyl cellulose K15M (HPMC K15M) were used as gelling agents. The prepared hydrogels were characterized for pH, viscosity, rheological behavior, spreadability, extrudability, swelling index, drug content, and accelerated stability. Based on physicochemical and in vitro permeation studies, PHGL1 containing aloe emodin (1%) and carbopol 940 (1%) was selected. The acute dermal toxicity study was also conducted as per the OECD guidelines 402. The mechanism of drug release followed Korsemeyer–Peppa’s model. The optimized batch showed a pH range from 6.867 ± 0.015 to 6.91 ± 0.254, drug content 94.6% ± 0.686% w/w of the active principle when studied in triplicate for drug content analysis, the measured viscosity of the formulation was 31402.33 ± 149.0783 mPaS exhibiting a shear thinning system along with thixotropic behavior at 25°C, and sustained drug release of 78% in 8 hours. An ex vivo permeation study demonstrated that 203.73 ?g/ml/cm 2 drug permeated through skin in 24 hours. Application of aloe emodin-loaded topical hydrogel to psoriatic skin resulted in a reduction of epidermal thickness, scaling, and ear thickness. The key inflammatory marker tissue necrosis factor (TNF-?) also showed a significant decrease. Compared with the marketed formulation, the test formulation showed no significant difference in the percentage reduction in ear thickness. No acute dermal toxicity was observed at the initial dose of 200 mg. The outcome suggests the promising potential of aloe emodin-loaded hydrogel in improving plaque-like psoriasis without dermal toxicity. Further studies are warranted to establish its efficacy in the management of psoriasis.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow, India; Department of Pharmaceutical Sciences, Gurukula Kangri (Deemed to be University), Haridwar, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Maharashtra, Mumbai, Indiaen_US
dc.identifier.affiliationsBabu Sunder Singh College of Pharmacy, Lucknow, India.en_US
dc.identifier.citationPandey A, Srivastava N, Dubey RC, Dhaneshwar S, Shukla AK. Anti-psoriatic evaluation of aloe emodin-loaded topical hydrogel in an imiquimod-induced human plaque-type psoriasis in BALB/c mice. Journal of Applied Pharmaceutical Science. 2024 Sept; 14(9): 279-291en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237708
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.199942en_US
dc.subjectAnthraquinoneen_US
dc.subjectAloe veraen_US
dc.subjectformulationen_US
dc.subjectPASI scoreen_US
dc.subjectcarbopol 940en_US
dc.subjectskin inflammation.en_US
dc.titleAnti-psoriatic evaluation of aloe emodin-loaded topical hydrogel in an imiquimod-induced human plaque-type psoriasis in BALB/c miceen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
japs2024v14n9p279.pdf
Size:
1.6 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Applied Pharmaceutical Science (JAPS)