Isolation modifies the behavioural response in rats.

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dc.contributor.authorKarim, Aen_US
dc.contributor.authorArslan, M Ien_US
dc.date.accessioned2000-04-24en_US
dc.date.accessioned2009-05-27T03:47:02Z
dc.date.available2000-04-24en_US
dc.date.available2009-05-27T03:47:02Z
dc.date.issued2000-04-24en_US
dc.descriptionBangladesh Medical Research Council Bulletin.en_US
dc.description.abstractTwenty-four male wister rats were reared from weaning either alone (isolation reared) or in groups of five (socially reared) for 6 weeks. Thereafter, the present study examined and compared the behaviour of isolation and socially reared rats in the test of social interaction, in the elevated plus-maze test of anxiety, in the open field behavior of exploration and locomotion activity, and the depressive behaviour in forced swim test. Under high light in unfamiliar conditions isolation reared rats spent significantly more time in aggressive interactions (P < 0.05) and high levels of aggressive behaviour compared to the socially reared rats (P < 0.05). Isolation reared rats had spent less time in the open arms than the socially reared rats in the maze test (P < 0.05). Isolation reared rats were more exploratory than the socially reared rats in the open field test and the defaecation scores were less compared to the socially reared controls (P < 0.05). Isolated rats spent less time immobile on the rats' forced swim test behaviour but the difference was not statistically significant. These findings suggest that isolation reared rats are nervous, aggressive and hyperactive animals in a novel field. It appears that isolation rearing in the early stages of life has modified a variety of behaviour in the adult rats, and the investigation of the pattern of behavioural changes in isolation reared rats may help to explore the environmental influences on the development of human psychopathology.en_US
dc.description.affiliationPharmacology Department, SSMC, Mitford, Dhaka.en_US
dc.identifier.citationKarim A, Arslan MI. Isolation modifies the behavioural response in rats. Bangladesh Medical Research Council Bulletin. 2000 Apr; 26(1): 27-32en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245
dc.language.isoengen_US
dc.source.urihttps://www.banglajol.info/index.php/BMRCB/indexen_US
dc.subject.meshAggression --physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnxiety --psychologyen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshDefecation --physiologyen_US
dc.subject.meshDepression --psychologyen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshExploratory Behavior --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLocomotion --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSocial Behavioren_US
dc.subject.meshSocial Isolationen_US
dc.subject.meshSocializationen_US
dc.subject.meshStress, Physiological --physiopathologyen_US
dc.titleIsolation modifies the behavioural response in rats.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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