Routes of transmission in the hepatitis E epidemic of Saharanpur.

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dc.contributor.authorSingh, Ven_US
dc.contributor.authorSingh, Ven_US
dc.contributor.authorRaje, Men_US
dc.contributor.authorNain, C Ken_US
dc.contributor.authorSingh, Ken_US
dc.date.accessioned1998-07-26en_US
dc.date.accessioned2009-06-04T04:14:21Z
dc.date.available1998-07-26en_US
dc.date.available2009-06-04T04:14:21Z
dc.date.issued1998-07-26en_US
dc.description.abstractA large waterborne epidemic of hepatitis E occurred in the city of Saharanpur (Uttar Pradesh, India) between December 1992 and April 1993. A random survey was conducted in the affected area of Saharanpur. Source of water supply, number of family members, number and characteristics of affected persons were noted. Blood, stool and water samples were collected. The incidence of hepatitis was 14% in the affected area of the city. A total of 3682 individuals were affected with the disease. Attack rate for adults was significantly higher than the children aged < 15 years (17% vs 7%; p < 0.0001). Among the adults, the attack rate was higher for males than females (23% vs 12%; p < 0.0001). The incidence of hepatitis was greater in persons using the municipal water supply (17%) as compared to hand pump (0.9%) or tubewell water (0%). There was a single peak in the epidemic. Of the 56 fresh cases, 38 (64%) occurred within two weeks, 14 within 2-4 weeks and 4 within 4-6 weeks of index cases. Serologic markers for acute hepatitis A, B and C were absent. IgM anti-HEV was positive in 20 out of 24 sera tested. Immune electron microscopy detected 27-34 nm virus-like particles (VLPs) in 2 of 8 stool specimens and in 1 of 3 water samples. The epidemic occurred due to leakage of municipal water supply pipes passing through the sewerage holes. A large waterborne epidemic of hepatitis E resulted due to contaminated water supply. VLPs were detected in water. Adults and males were commonly affected. There was no person-to-person spread.en_US
dc.description.affiliationPostgraduate Institute of Medical Education and Research, Chandigarh, India.en_US
dc.identifier.citationSingh V, Singh V, Raje M, Nain CK, Singh K. Routes of transmission in the hepatitis E epidemic of Saharanpur. Tropical Gastroenterology. 1998 Jul-Sep; 19(3): 107-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124794
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis E --blooden_US
dc.subject.meshHepatitis E virus --isolation & purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Infectious --epidemiologyen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshWater Microbiologyen_US
dc.subject.meshWater Supplyen_US
dc.titleRoutes of transmission in the hepatitis E epidemic of Saharanpur.en_US
dc.typeJournal Articleen_US
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