A comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions.

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dc.contributor.authorDeshmukh, A Ren_US
dc.contributor.authorDhurat, R Sen_US
dc.contributor.authorJerajani, H Ren_US
dc.contributor.authorJerajani, U Ren_US
dc.date.accessioned2003-07-23en_US
dc.date.accessioned2009-05-28T10:37:02Z
dc.date.available2003-07-23en_US
dc.date.available2009-05-28T10:37:02Z
dc.date.issued2003-07-23en_US
dc.description.abstractA controlled clinical and histopathological study was carried out to compare the efficacy of a combination of rifampicin 600 mg plus ofloxacin 400 mg plus minocycline 100 mg (ROM) administered as a single dose with that of standard WHO/MDT-PB six months' regimen with regard to resolution of lesion clinically and histopathologically. Skin biopsy was performed at the intake and at 6 months. The study subjects were 32 previously untreated, smear-negative patients, without nerve trunk involvement and having 1-3 skin lesions. The results were analyzed for mean clinical score for marked, moderate and no improvement and mean histopathological score was graded as active, resolving and complete resolution, according to granuloma fraction at the end of 6 months. Marked clinical improvement was seen in 25% and 12%, moderate improvement in 50% and 56% patients treated with ROM and standard regimens respectively. Histopathologically, activity was seen in 62.5% and 43.7% and resolution of granuloma in 25% and 31.2% in the ROM and standard regimens respectively. Both the regimens were equally efficacious in the reduction of clinical score and granuloma fraction. No adverse drug reactions or reversal reactions were seen during the study period in both the groups.en_US
dc.description.affiliationDepartment of Dermatology, Venerology and Leprosy, Lokmanya Tilak Municipal Medical College, Mumbai 400022.en_US
dc.identifier.citationDeshmukh AR, Dhurat RS, Jerajani HR, Jerajani UR. A comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions. Indian Journal of Leprosy. 2003 Jul-Sep; 75(3): 209-17en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55587
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Bacterial Agents --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprostatic Agents --administration & dosageen_US
dc.subject.meshLeprosy --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMinocycline --administration & dosageen_US
dc.subject.meshOfloxacin --administration & dosageen_US
dc.subject.meshRifampin --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleA comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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