Coagulation profile tests as a predictor for adult trauma patients’ mortality

Simple item page
dc.contributor.authorFawzy, Ahmeden_US
dc.contributor.authorLolah, Magdyen_US
dc.contributor.authorIbrahim, Samah Saaden_US
dc.contributor.authorHassan, Alaa Efaten_US
dc.date.accessioned2020-11-18T10:03:44Z
dc.date.available2020-11-18T10:03:44Z
dc.date.issued2020-01
dc.description.abstractBackground: Coagulopathy is commonly observed in poly-traumatized patients and is a known contributor to trauma mortality. Although, the incidence of coagulopathy is strongly associated with the severity of the injury, coagulopathy itself exerts an independent factor on mortality.Methods: This is a prospective, observational study on 100 trauma patients. All patients were evaluated using the modified shock index (MSI). Coagulation profile tests including platelet count, prothrombin time (PT), partial thromboplastin time (PTT), D-dimer and fibrinogen/fibrin degradation products (FDPs) were performed for all patients on admission and at 12 hours intervals. Statistically, a logistic regression analysis was performed of coagulation profile tests to determine the incidence of trauma induced coagulopathy (TIC) and its impact on 24 hours mortality. Correlation between clinical and laboratory status was done.Results: There was a statistically significant difference between the dead and the survived patients in the coagulation profile tests and MSI. The best cut-off point of each parameter of coagulation profile tests (PLT count, PT, PTT, d-dimer, FDPs) and MSI was calculated using receiver operating characteristic curve and were <173 × 109/l, >18.7 s, >31 s, >5 mg/l, > 321.5 mg/l and 1.6 respectively. Trauma induced coagulopathy in our study was defined by more than 2 of the following: PLT <173 × 109/l, PT >18.7 s, activated partial thromboplastin time (APTT) >31 s, D-dimer >5 mg/l and FDPs>321.5 mg/l with a p value 0.001 and associated with increased mortality.Conclusions: The incidence of trauma induced coagulopathy early after trauma is high and its severity is related to the injury itself. It is independent predictor of mortality. TIC was developed with presence of more than 2 of the coagulopathy parameters.en_US
dc.identifier.affiliationsDepartment of Surgery, Faculty of Medicine, Menoufia University, Egypten_US
dc.identifier.affiliationsDepartment of Surgery, Faculty of Medicine, Taibah University, Saudia Arabiaen_US
dc.identifier.affiliationsEmergency Department, Faculty of Medicine, Menoufia University, Egypten_US
dc.identifier.affiliationsDepartment of Internal Medicine, Faculty of Medicine, Menoufia University, Egypten_US
dc.identifier.citationFawzy Ahmed, Lolah Magdy, Ibrahim Samah Saad, Hassan Alaa Efat. Coagulation profile tests as a predictor for adult trauma patients’ mortality. International Surgery Journal. 2020 Jan; 7(1): 1-9en_US
dc.identifier.issn2349-3305
dc.identifier.issn2349-2902
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212662
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-2902.isj20195942en_US
dc.subjectCoagulopathyen_US
dc.subjectTrauma patientsen_US
dc.subjectplateletsen_US
dc.subjectD-Dimeren_US
dc.subjectMSIen_US
dc.titleCoagulation profile tests as a predictor for adult trauma patients’ mortalityen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
isj2020v7n1p1.pdf
Size:
496.9 KB
Format:
Adobe Portable Document Format
Download
Collections
International Surgery Journal