The efficacy of granisetron for cancer patients undergoing platinum-based chemotherapy: comparison of 1 miligram versus 3 miligram doses in preventing nausea and vomiting.

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dc.contributor.authorKurnianda, Johanen_US
dc.contributor.authorHisyam, Barmawien_US
dc.contributor.authorWahyuningsih, Endangen_US
dc.contributor.authorHutajulu, Susanna Hen_US
dc.date.accessioned2005-10-01en_US
dc.date.accessioned2009-05-28T04:35:14Z
dc.date.available2005-10-01en_US
dc.date.available2009-05-28T04:35:14Z
dc.date.issued2005-10-01en_US
dc.description.abstractAIM: To compare the efficacy of anti-emetic and prophylactic effects of 1 milligram (mg) versus 3 mg granisetron in cancer patients. METHODS: In this double blind, randomized, parallel study, 2-dose regimens of intra venous (IV) granisetron were evaluated in 39 cancer patients who were treated with platinum-based chemotherapy. Patients who met the inclusion criteria were randomized to receive granisetron 1 mg IV plus dexamethasone 20 mg (group A) or granisetron 3 mg iv plus dexamethasone 20 mg (group B). A questionnaire was used to evaluate the anti-emetic effects of granisetron. RESULTS: Subjects consisted of 31 men and 8 women. In group A (19 patients) 57.9% showed complete response from vomiting, 10.5% of major response, and 31.6% of failure to anti-emetic therapy. There were 47.4% of patients free from nausea and 52.6% complained of nausea (mild, moderate, and severe nausea). Among group B (20 patients), 90% showed complete response from vomiting, 5% of major response, and 5% of failure to anti-emetic therapy. Eighty percent of patients were free from nausea, while 15% complained of mild nausea and 5% of moderate nausea. The differences were statistically significant for vomiting (p = 0.02) as well as for nausea (p = 0.03). CONCLUSION: Intravenous granisetron 3 mg has better efficacy than granisetron 1 mg in preventing cisplatin- induced acute emesis.en_US
dc.description.affiliationDepartment of Internal Medicine Faculty of Medicine, Gadjah Mada University, Yogyakarta.en_US
dc.identifier.citationKurnianda J, Hisyam B, Wahyuningsih E, Hutajulu SH. The efficacy of granisetron for cancer patients undergoing platinum-based chemotherapy: comparison of 1 miligram versus 3 miligram doses in preventing nausea and vomiting. Acta Medica Indonesiana. 2005 Oct-Dec; 37(4): 210-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/47116
dc.language.isoengen_US
dc.subject.meshAdulten_US
dc.subject.meshAntiemetics --administration & dosageen_US
dc.subject.meshAntineoplastic Agents --adverse effectsen_US
dc.subject.meshCisplatin --adverse effectsen_US
dc.subject.meshDexamethasone --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshGranisetron --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNausea --chemically induceden_US
dc.subject.meshNeoplasms --drug therapyen_US
dc.subject.meshPremedicationen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVomiting --chemically induceden_US
dc.titleThe efficacy of granisetron for cancer patients undergoing platinum-based chemotherapy: comparison of 1 miligram versus 3 miligram doses in preventing nausea and vomiting.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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