Cardioprotective, antioxidant activities and Phytochemical analysis by GC-MS of Gmelina arborea (GA) in Doxorubicin-induced myocardial necrosis in Albino rats.

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dc.contributor.authorVijay, T
dc.contributor.authorRajan, M S Dhana
dc.contributor.authorSarumathy, K
dc.contributor.authorPalani, S
dc.contributor.authorSakthivel, K
dc.date.accessioned2014-05-14T04:01:36Z
dc.date.available2014-05-14T04:01:36Z
dc.date.issued2011-07
dc.description.abstractDoxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with Gmelina arborea (Verbenaceae) were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of Gmelina arborea (GA) against DOX- induced cardiotoxicity in rats. GA was given orally to rats(250&500mg/kg) and DOX (20mg/kg) was administered on the seventh day. GA protected against DOX-induced increased the levels of marker enzymes. It significantly inhibited DOX-provoked glutathione (GSH) depletion in cardiac tissues. The reductions of cardiac activities of catalase (CAT) ,superoxide dismutase (SOD) ,glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Pretreatment of GA significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH). GA alleviated histopathological changes in rats’ hearts treated with DOX. In conclusion, GA protects against DOX-induced cardiotoxicity in rats. The study can be attributed, at least in part, to GA’s antioxidant activity.en_US
dc.identifier.citationVijay T, Rajan M S Dhana, Sarumathy K, Palani S, Sakthivel K. Cardioprotective, antioxidant activities and Phytochemical analysis by GC-MS of Gmelina arborea (GA) in Doxorubicin-induced myocardial necrosis in Albino rats. Journal of Applied Pharmaceutical Science. 2011 July; 1(5): 198-204.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150838
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=112en_US
dc.subjectCardiotoxicityen_US
dc.subjectDoxorubicinen_US
dc.subjectantioxidanten_US
dc.subjectGmelina arboreen_US
dc.subjecthistopathological changesen_US
dc.titleCardioprotective, antioxidant activities and Phytochemical analysis by GC-MS of Gmelina arborea (GA) in Doxorubicin-induced myocardial necrosis in Albino rats.en_US
dc.typeArticleen_US
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