Comparison of the Locoregional Outcome, Toxicities, and Compliance between Hypofractionated and Conventional Chemoradiotherapy for Head‑and‑Neck Cancers

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dc.contributor.authorSharma, Jyotien_US
dc.contributor.authorLoyal, Anushreeen_US
dc.contributor.authorDhal, Shikhaen_US
dc.contributor.authorGoyal, Sumiten_US
dc.contributor.authorKapoor, Tapanen_US
dc.contributor.authorRajendra, Ishitaaen_US
dc.contributor.authorSingh, D.P.en_US
dc.date.accessioned2023-07-14T07:59:05Z
dc.date.available2023-07-14T07:59:05Z
dc.date.issued2022-06
dc.description.abstractIntroduction:Head‑and‑neck cancer (HNC) treatments are elusive, and the hunt for an appropriate radiation strategy continues.Hypofractionation has the potential to provide several advantages, including a shorter overall duration that reduces rapid repopulation, dosage escalation with a higher biologically effective dose, and patient convenience. Hypofractionation is also beneficial in minimizing the danger of catching an infectious agent by reducing the number of hospital visits during the height of the COVID‑19 epidemic. Materials and Methods: Between January 2020 and August 2021, 120 patients with squamous cell carcinoma of the head‑and‑neck subsites were randomly allocated to either the hypofractionated arm A (n = 60) or the standard fractionation arm B (n = 60) with concomitant treatment. Results:Locoregional tumor response, acute and late toxicity, and compliance were the study’s endpoints. The normal tissue toxicities of each patient undergoing radiation were monitored weekly. Clinical and radiographic evaluations of locoregional control were conducted. Conclusion:Hypofractionation effectively overcomes tumor repopulation in rapidly growing tumors such as HNC, and we conclude in our study that the hypofractionated chemoradiation schedule appears to be more efficacious, with relatively superior locoregional control when compared to conventional chemoradiation with comparable normal tissue toxicities and complianceen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Sri Ram Cancer Center, Mahatma Gandhi Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.citationSharma Jyoti, Loyal Anushree, Dhal Shikha, Goyal Sumit, Kapoor Tapan, Rajendra Ishitaa, Singh D. P.. Comparison of the Locoregional Outcome, Toxicities, and Compliance between Hypofractionated and Conventional Chemoradiotherapy for Head‑and‑Neck Cancers. Acta Medica International. 2022 Jun; 9(1): 21-25en_US
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219173
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://doi.org/10.4103/amit.amit_40_22en_US
dc.subjectConventionalen_US
dc.subjecthead‑and‑neck cancersen_US
dc.subjecthypofractionationAden_US
dc.titleComparison of the Locoregional Outcome, Toxicities, and Compliance between Hypofractionated and Conventional Chemoradiotherapy for Head‑and‑Neck Cancersen_US
dc.typeJournal Articleen_US
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