CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS

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dc.contributor.authorPiyawan Bunpoen_US
dc.contributor.authorKeiko Kataokaen_US
dc.contributor.authorHideki Arimochien_US
dc.contributor.authorHaruyuki Nakayamaen_US
dc.contributor.authorTomomi Kuwaharaen_US
dc.contributor.authorYoshinari Ohnishien_US
dc.contributor.authorUsanee Vinitketkumnuenen_US
dc.date.accessioned2011-02-16T09:15:48Z
dc.date.available2011-02-16T09:15:48Z
dc.date.created2009-12-22en_US
dc.date.issued2009-12-22en_US
dc.description.abstractCentella asiatica  is traditionally a medicinal plant frequently employed in the practice of Thai folk medicine. This study examined the anti-tumor activity of the crude water extract of C. asiatica using human colon adenocarcinoma-derived Caco-2 cells. C. asiatica extract reduced the proliferation rate of Caco-2 cells significantly in a concentration- and time-dependent manner. The mechanism of cancer cell growth inhibition was shown to occur via cell cycle arrest. The extract induced S and G2-M arrest in Caco-2 cells accompanied apoptosis induction. The extract also increased the accumulation of cyclin B1 protein in the cells. These findings indicate that C. asiatica extract inhibited cell proliferation of Caco-2 cells through modification of the cell cycle events and this cell cycle arrest is associated, at least in part, with increased accumulation of cyclin B1 protein. Chiang Mai Med Bull 2005;44(1):21-28.en_US
dc.identifier.citationChiang Mai Medical Journal; Vol.44 No.1 March 2005 (pages 1-47); 21 - 28en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130644
dc.language.isoen_USen_US
dc.publisherChiang Mai Medical Journalen_US
dc.rightsChiang Mai Medical Journalen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/CMMJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/CMMJ/article/view/754en_US
dc.titleCENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLSen_US
dc.typeOriginal Articlesen_US
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