Alleviation of the climacteric symptoms with oral sequential hormone replacement therapy.

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dc.contributor.authorChittacharoen, Apicharten_US
dc.contributor.authorDomhardt, Reineren_US
dc.contributor.authorManonai, Jittimaen_US
dc.contributor.authorTheppisai, Urusaen_US
dc.contributor.authorGolbs, Siegfrieden_US
dc.date.accessioned2009-05-27T18:58:26Z
dc.date.available2009-05-27T18:58:26Z
dc.date.issued2004-01-20en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe efficacy of the oral hormone replacement therapy (HRT) preparation estradiol valerate/levonorgestrel (EV/LNG, Klimonorm) in the alleviation of the menopausal complaints of peri- and postmenopausal Thai women was studied in a prospective, open, uncontrolled phase IV clinical trial. Of the 50 peri- or postmenopausal women screened, 39 completed the study. From them 31 were postmenopausal and 8 perimenopausal. The participants received EV/LNG over a period of 6 cycles. The Menopause Rating Scale II (MRS II) was used to assess the effect of EV/LNG on the menopausal symptoms. The changes in the main parameters of the MRS II during the treatment with EV/LNG showed that the general score decreased by 34.9 per cent after 3 months and was kept at the same value after 6 months of treatment. The somato-vegetative complaints decreased by 32.5 per cent after 3 months and by 35 per cent after 6 months. The psychological complaints decreased by 34.1 per cent after 3 months and by 32.9 per cent after 6 months. The urogenital complaints decreased by 29.3 per cent after 3 months, and remained at the same level after 6 months of treatment. In conclusion, the 6-months administration of the oral HRT preparation estradiol valerate/levonorgestrel caused a considerable alleviation of the climacteric symptoms in menopausal women.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationChittacharoen A, Domhardt R, Manonai J, Theppisai U, Golbs S. Alleviation of the climacteric symptoms with oral sequential hormone replacement therapy. Journal of the Medical Association of Thailand. 2004 Jan; 87(1): 1-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40219
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshClimacteric --drug effectsen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshEstradiol --analogs & derivativesen_US
dc.subject.meshEstrogen Replacement Therapy --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLevonorgestrel --pharmacologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.titleAlleviation of the climacteric symptoms with oral sequential hormone replacement therapy.en_US
dc.typeClinical Trialen_US
dc.typeClinical Trial, Phase IVen_US
dc.typeJournal Articleen_US
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