Toxicity Study of Lupinifolin from Stem of Derris reticulata Craib

dc.contributor.authorSongpol Chivapaten_US
dc.contributor.authorPranee Chavalittumrongen_US
dc.contributor.authorAimmanas Attawishen_US
dc.date.accessioned2011-02-21T08:21:26Z
dc.date.available2011-02-21T08:21:26Z
dc.date.created2010-07-07en_US
dc.date.issued2010-07-07en_US
dc.description.abstractLupinifolin is a flavonone compound expressing high efficacy against Herpes simplex virus 1 (HSV-1). The objective of this study was to investigate the toxicity of lupinifolin from the stem of Derris reticulata Craib. Oral administration of lupinifolin in mice at the dose of 5 mg/kg, which was equivalent to an 8,300-fold therapeutic dose, showed no acute toxicity. A subacute toxicity study was performed on six groups of Wistar rats for 28 days. Groups 1 and 2 were control groups given distilled water and 1 percent tragacanth, respectively. Groups 3 to 6 were administered lupinifolin orally at doses of 0.6, 6.0, 3.0 and 60 mg/kg/day, which were equivalent to 1, 10, 50 and 100 times the therapeutic dose, respectively. The results revealed that lupinifolin did not affect body weight, food consumption or the animals’ health. Female rats receiving lupinifolin at the dose of 60 mg/kg/day had a significant increase in WBC and a significant decrease in neutrophils when compared with the water control group, but these changes were within normal ranges. Male rats receiving lupinifolin at doses of 30 and 60 mg/kg/day and female rats receiving lupinifolin at 60 mg/kg/day had a significantly higher sodium level than the water control groups; nevertheless, the increase was within the normal range. The potassium level in female rats receiving lupinifolin at doses of 30 and 60 mg/kg/day was significantly lower than that of the water control group. Histopathological results of some visceral organs in the lupinifolintreated groups showed no dose-dependent alterations; therefore, lupinifolin from D. reticulata should be considered safe for the treatment of HSV1-infected wounds.en_US
dc.identifier.citationJournal of Traditional Thai \& Alternative Medicine; Vol. 7 No. 2-3 May-December 2009; 146-155en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/131275
dc.language.isoen_USen_US
dc.publisherDepartment for Development of Thai and Alternative Medicineen_US
dc.rightsDepartment for Development of Thai Traditional and Alternative Medicine, Ministry of Public Health, Bangkok, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JTTAM/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JTTAM/article/view/4214en_US
dc.titleToxicity Study of Lupinifolin from Stem of Derris reticulata Craiben_US
dc.typeOriginal Articleen_US
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