Valproate-induced hyperammonemic encephalopathy with normal liver function.

Simple item page
dc.contributor.authorRath, Amitaven_US
dc.contributor.authorNaryanan, T Jaishreeen_US
dc.contributor.authorChowdhary, G V Sen_US
dc.contributor.authorMurthy, J M Ken_US
dc.date.accessioned2005-06-13en_US
dc.date.accessioned2009-06-03T12:18:53Z
dc.date.available2005-06-13en_US
dc.date.available2009-06-03T12:18:53Z
dc.date.issued2005-06-13en_US
dc.description.abstractHyperammonemic encephalopathy with normal liver function is an uncommon serious adverse effect of valproate therapy. We retrospectively analyzed the case records of 5 patients of epilepsy on valproate with hyperammonemic encephalopathy. Of the 5 patients, 3 were on monotherapy. The mean valproate dose was 1250 mg/day and the duration of therapy ranged between 4 and 90 days. Alteration in the sensorium was the presenting clinical feature. The risk factors included high initial dose (2), long-term valproate therapy (1), and long-term valproate therapy with concomitant topiramate (1). There was good correlation between the fall in serum ammonia levels and clinical improvement. Hyperammonemic encephalopathy should be suspected in patients on valproate with altered sensorium. Response to treatment is rewarding.en_US
dc.description.affiliationDepartment of Neurology, The Institute of Neurological Sciences, CARE Hospital, Hyderabad, India.en_US
dc.identifier.citationRath A, Naryanan TJ, Chowdhary GV, Murthy JM. Valproate-induced hyperammonemic encephalopathy with normal liver function. Neurology India. 2005 Jun; 53(2): 226-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121471
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnticonvulsants --adverse effectsen_US
dc.subject.meshEpilepsy --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver --physiologyen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRett Syndrome --chemically induceden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshValproic Acid --adverse effectsen_US
dc.titleValproate-induced hyperammonemic encephalopathy with normal liver function.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Neurology India