Compliance monitoring in epileptic patients.

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dc.contributor.authorChandra, R Sen_US
dc.contributor.authorDalvi, S Sen_US
dc.contributor.authorKarnad, P Den_US
dc.contributor.authorKshirsagar, N Aen_US
dc.contributor.authorShah, P Uen_US
dc.date.accessioned1993-07-01en_US
dc.date.accessioned2009-05-30T22:23:31Z
dc.date.available1993-07-01en_US
dc.date.available2009-05-30T22:23:31Z
dc.date.issued1993-07-01en_US
dc.description.abstractPoor patient compliance is one of the major causes of non responsiveness to antiepileptic drug therapy. Compliance is mostly assessed by self reporting, pill counting and plasma drug level estimation. However, none of them is fool proof. Subtherapeutic plasma drug levels can be due to poor compliance or need for higher dosage. Therefore, in the present study, 20 adult non responsive epileptic patients showing subtherapeutic plasma phenytoin levels inspite of receiving standard phenytoin therapy and history of good compliance were admitted in the clinical pharmacology ward and received supervised drug treatment for five days after which plasma phenytoin levels in 14 patients increased to therapeutic range. All except one (i.e. 9 out of 10) patients showing phenytoin levels < 5 ug/ml inspite of phenytoin dosage of > 300 mg/d and history of good compliance were found to be noncompliant. Hence adult patient receiving greater than or equal to 300 mg/day phenytion and showing phenytoin levels less than or equal to 5 ug/ml should be investigated for possible noncompliance before altering their dosage schedules.en_US
dc.description.affiliationDepartment of Pharmacology, Seth GS Medical College, Bombay.en_US
dc.identifier.citationChandra RS, Dalvi SS, Karnad PD, Kshirsagar NA, Shah PU. Compliance monitoring in epileptic patients. Journal of the Association of Physicians of India. 1993 Jul; 41(7): 431-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/89483
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshEpilepsy, Tonic-Clonic --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshPhenytoin --blooden_US
dc.titleCompliance monitoring in epileptic patients.en_US
dc.typeJournal Articleen_US
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